Systemic rheumatic diseases have significant morbidity and mortality, due in large part to concurrent infections. The lung has been reported among the most frequent sites of infection in patients with rheumatic disease, who are susceptible to developing pneumonia sustained both by common pathogens and by opportunistic microorganisms. Patients with rheumatic disease show a peculiar vulnerability to infectious complications. This is due in part to intrinsic disease-related immune dysregulation and in part to the immunosuppressive treatments. Several therapeutic agents have been associated to a wide spectrum of infections, complicating the management of rheumatic diseases. This review discusses the most frequent pulmonary infections encountered in rheumatic diseases, focusing on opportunistic agents, consequent diagnostic challenges and appropriate therapeutic strategies.

Lung Infections in Systemic Rheumatic Disease:Focus on Opportunistic Infections / Manuela Di, Franco; Lucchino, Bruno; Spaziante, Martina; Iannuccelli, Cristina; Valesini, Guido; Giancarlo, Iaiani. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - STAMPA. - 19(2017), pp. 1-19. [10.3390/ijms18020293]

Lung Infections in Systemic Rheumatic Disease:Focus on Opportunistic Infections

SPAZIANTE, MARTINA;IANNUCCELLI, Cristina;VALESINI, Guido;
2017

Abstract

Systemic rheumatic diseases have significant morbidity and mortality, due in large part to concurrent infections. The lung has been reported among the most frequent sites of infection in patients with rheumatic disease, who are susceptible to developing pneumonia sustained both by common pathogens and by opportunistic microorganisms. Patients with rheumatic disease show a peculiar vulnerability to infectious complications. This is due in part to intrinsic disease-related immune dysregulation and in part to the immunosuppressive treatments. Several therapeutic agents have been associated to a wide spectrum of infections, complicating the management of rheumatic diseases. This review discusses the most frequent pulmonary infections encountered in rheumatic diseases, focusing on opportunistic agents, consequent diagnostic challenges and appropriate therapeutic strategies.
2017
rheumatic diseases; lung infections; opportunistic infections; anti-tumor necrosis factor(TNF); pneumonia
01 Pubblicazione su rivista::01a Articolo in rivista
Lung Infections in Systemic Rheumatic Disease:Focus on Opportunistic Infections / Manuela Di, Franco; Lucchino, Bruno; Spaziante, Martina; Iannuccelli, Cristina; Valesini, Guido; Giancarlo, Iaiani. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - STAMPA. - 19(2017), pp. 1-19. [10.3390/ijms18020293]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/926616
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