A rapid resolution liquid chromatography-tandem mass spectrometry analysis was applied to human urine samples to discover new molecular biomarkers of the alteration of psychophysical well-being due to the environmental, physiological and confinement stress conditions achieved in the MARS500 project. Urine samples of crew members were submitted to metabolomic studies by means of separative techniques coupled with mass spectrometric techniques and data analysis. More than 2,000 metabolite features were found in each comparison, and more than 150 metabolites were identified for every differential analysis. Significant modifications in eight metabolites were shared by the subjects under study.
Rapid Resolution Liquid chromatography/High Resolution Tandem Mass Spectrometry to Characterize Metabolic Changes in Subjects Involved in MARS500 Project / Capriotti, ANNA LAURA; Caruso, Giuseppe; Cavaliere, Chiara; Foglia, Patrizia; Bizzarri, Mariano; Lagana', Aldo. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - STAMPA. - 73:S1(2011), pp. S45-S53. (Intervento presentato al convegno 16th International Symposium on Separation Sciences, New Advancements in Chromatography and Capillary Electromigration Techniques (16th ISSS) tenutosi a Rome, ITALY nel SEP 06-10, 2010) [10.1007/s10337-010-1880-7].
Rapid Resolution Liquid chromatography/High Resolution Tandem Mass Spectrometry to Characterize Metabolic Changes in Subjects Involved in MARS500 Project
CAPRIOTTI, ANNA LAURA;CARUSO, Giuseppe;CAVALIERE, CHIARA;FOGLIA, Patrizia;BIZZARRI, Mariano;LAGANA', Aldo
2011
Abstract
A rapid resolution liquid chromatography-tandem mass spectrometry analysis was applied to human urine samples to discover new molecular biomarkers of the alteration of psychophysical well-being due to the environmental, physiological and confinement stress conditions achieved in the MARS500 project. Urine samples of crew members were submitted to metabolomic studies by means of separative techniques coupled with mass spectrometric techniques and data analysis. More than 2,000 metabolite features were found in each comparison, and more than 150 metabolites were identified for every differential analysis. Significant modifications in eight metabolites were shared by the subjects under study.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
