Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome lp.
Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset / Bonifati, Vincenzo; G. J., Breedvelt; A., Squitieri; Vanacore, Nicola; Pierluigi, Brustenghi; Biswadjiet S., Harhangi; Pasquale, Montagna; Milena, Cannella; Fabbrini, Giovanni; Patrizia, Rizzu; Meco, Giuseppe; Peter, Heutink. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 51:2(2002), pp. 253-256. [10.1002/ana.10106]
Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset
BONIFATI, Vincenzo;VANACORE, NICOLA;FABBRINI, Giovanni;MECO, Giuseppe;
2002
Abstract
Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome lp.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
