Multiple system atrophy (MSA) is a form of atypical parkinsonism with unknown etiology. The epidemiological studies conducted up to now on this disease are scarce. The incidence rate is about 0.6 cases per 100 000 persons per year. The prevalence rates show 4-5 cases per 100 000 persons. In Italy, about 4900 prevalent cases have been estimated. The mean onset age is about 54 years; the median survival is 7-9 years. Only one case-control study has been performed on this disease. This study showed an increased risk of MSA associated with occupational exposure to organic solvents, plastic monomers and additives, pesticides and metals. Smoking habits seem to be less frequent in MSA cases (as in Parkinson's disease cases) than in healthy controls. Quinn's clinical criteria and those of the Consensus Conference promoted by the American Academy of Neurology are in fair agreement. We have performed a case-control study on 73 MSA cases, 146 hospital controls and 73 population controls.
Epidemiology of multiple system atrophy. ESGAP Consortium. European Study Group on Atypical Parkinsonisms / Vanacore, Nicola; Bonifati, Vincenzo; Fabbrini, Giovanni; Colosimo, Carlo; G., De Michele; R., Marconi; D., Nicholl; Locuratolo, Nicoletta; Talarico, Giuseppina; Romano, Silvia; F., Stocchi; Meco, Giuseppe; Bonuccelli, U; DE MARI, GUIDO MARIA; Vieregge, P. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 22:1(2001), pp. 97-99. (Intervento presentato al convegno XVIIth LIMPE Annual Meeting tenutosi a DOMUS DE MARIA, ITALY nel OCT 25-27, 2000) [10.1007/s100720170064].
Epidemiology of multiple system atrophy. ESGAP Consortium. European Study Group on Atypical Parkinsonisms
VANACORE, NICOLA;BONIFATI, Vincenzo;FABBRINI, Giovanni;COLOSIMO, Carlo;LOCURATOLO, NICOLETTA;TALARICO, GIUSEPPINA;ROMANO, SILVIA;MECO, Giuseppe;DE MARI, GUIDO MARIA;
2001
Abstract
Multiple system atrophy (MSA) is a form of atypical parkinsonism with unknown etiology. The epidemiological studies conducted up to now on this disease are scarce. The incidence rate is about 0.6 cases per 100 000 persons per year. The prevalence rates show 4-5 cases per 100 000 persons. In Italy, about 4900 prevalent cases have been estimated. The mean onset age is about 54 years; the median survival is 7-9 years. Only one case-control study has been performed on this disease. This study showed an increased risk of MSA associated with occupational exposure to organic solvents, plastic monomers and additives, pesticides and metals. Smoking habits seem to be less frequent in MSA cases (as in Parkinson's disease cases) than in healthy controls. Quinn's clinical criteria and those of the Consensus Conference promoted by the American Academy of Neurology are in fair agreement. We have performed a case-control study on 73 MSA cases, 146 hospital controls and 73 population controls.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
