Nucleophosmin is a shuttleing protein mainly localizated in nucleolus. It is involved in many different cellular processes like ribogenesis, centrosome duplication, apoptotic response. In more then 35% of Acute Myeloyd Leukemic patient with Normal Kariotype, the Nucleophosmin gene is mutated, causing aberrant cytoplasmatic accumulation, imparing DNA binding activity. In this work we describe the structural and functional feuteres of Nucleophosmin DNA binding domain, to better understand its activy both in phisiological and pathologial conditions.
Structural and functional characterization of Nucleophosmin domain associated with Acute Myeoloid Leukemia / LO STERZO, Carlo. - (2013 Mar 01).
Structural and functional characterization of Nucleophosmin domain associated with Acute Myeoloid Leukemia
LO STERZO, CARLO
01/03/2013
Abstract
Nucleophosmin is a shuttleing protein mainly localizated in nucleolus. It is involved in many different cellular processes like ribogenesis, centrosome duplication, apoptotic response. In more then 35% of Acute Myeloyd Leukemic patient with Normal Kariotype, the Nucleophosmin gene is mutated, causing aberrant cytoplasmatic accumulation, imparing DNA binding activity. In this work we describe the structural and functional feuteres of Nucleophosmin DNA binding domain, to better understand its activy both in phisiological and pathologial conditions.| File | Dimensione | Formato | |
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tesi Carlo Lo Sterzo.pdf
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Note: Tesi Carlo Lo Sterzo
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13.7 MB | Adobe PDF |
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