Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades 11 and 111), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p 13. 1-p 13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma / Annalisa, Pezzolo; Valeria, Capra; Alessandro, Raso; Fabio, Morandi; Federica, Parodi; Claudio, Gambini; Paolo, Nozza; Giangaspero, Felice; Armando, Cama; Vito, Pistoia. - In: CANCER LETTERS. - ISSN 0304-3835. - 261:2(2008), pp. 235-243. [10.1016/j.canlet.2007.11.021]
Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma
GIANGASPERO, FELICE;
2008
Abstract
Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades 11 and 111), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p 13. 1-p 13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings. (C) 2007 Elsevier Ireland Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
