The Deep Brain Stimulation (DBS) is a successful clinic technique in reducing symptoms of Parkinson's disease. However the underlying mechanisms of action are still largely unknown. In order to evaluate an accurate calculation of the electric quantities induced by the stimulation inside the brain structures, we have developed an 2-D and an 3-D dosimetric model, encompassing the anatomic structures affected by neural stimulation, the surrounding environment, and the stimulating electrode. The dosimetric model has been used to predict the effect of the stimulation on neuronal fibers and for an exact quantification of the fundamental electrical quantities inside the anatomical target. This exogenous quantities become an input for the biophysical neuronal model in order to evaluate the neuronal response. Moreover, a bi-compartimental biophysical model has been developed, exhibiting a good match with the experimental recordings of a sub-thalamic neuron (STN). In conclusion, dosimetric and biophysical models have been able to reproduce both experimental data of STN soma inhibition and STN axon excitation induced by DBS.
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