The aim of the present study was to investigate in healthy subjects whether continuous theta-burst stimulation (cTBS) applied over the lateral cerebellum alters motor learning (acquisition and retention phases) during ipsilateral simple and complex movements. Eighteen healthy subjects participated in the study. We delivered cTBS over the lateral cerebellum immediately before a motor learning task involving repeated simple (i.e. index finger-abductions) and complex (i.e. reaching) movements. As motor learning measures we evaluated kinematic variables for simple and complex movements during the task. To see whether cerebellar cTBS-induced changes in motor learning take place through changes in primary motor cortex (M1) activity we used single-pulse transcranial magnetic stimulation (TMS) and evaluated changes in motor evoked potential (MEP) amplitude throughout the experiment. Cerebellar cTBS left the practice-related increase in peak acceleration unchanged but decreased peak acceleration for index finger and reaching movements during motor retention. The smoothness and straightness for trajectories related to reaching movements remained unchanged. When subjects repeated simple and complex movements performed alone, M1 excitability, as measured by the TMS-induced MEP facilitation, increased and MEP amplitudes increased more during simple movements than during complex movements. Cerebellar cTBS given before simple and complex movement tasks decreased the MEP facilitation induced by simple movements, whereas it increased the MEP facilitation induced by complex movements. During simple and complex movement tasks testing motor learning, no matter how complicated the motor task, cerebellar cTBS interferes with motor memory formation. cTBS induces changes in cerebellar activity thus altering motor-learning-related synaptic activity in M1.
|Titolo:||Interazione tra cTBS cerebellare e movimenti volontari semplici e complessi dell'arto superiore : nuove acquisizioni sui processi di plasticità omeostati e di formazione della memoria motoria|
|Data di pubblicazione:||26-feb-2013|
|Appartiene alla tipologia:||07b Tesi di Dottorato (EX-Padis)|