Interictal cerebrovascular reactivity to hypercapnia and middle cerebral arteries (MCA) mean flow velocities were investigated in 20 patients with high-frequency migraine (8 with aura and 12 without aura) and 19 age and sex-matched healthy controls by means the CO2 reactivity test. Patients were started on prophylactic treatment with topiramate 100 mg per day, and measurements were repeated after 8 weeks treatment. Baseline mean blood flow velocities were not different in the controls and patients. Cerebrovascular reactivity (VMR), calculated as the percentage increase in MCA velocity during the 90 seconds inhalation of a mixture of 7% CO2/air, was found to be significantly greater (p < 0.01) in both patient groups compared with the controls, showing an exaggerated reactivity to hypercapnia in migraineurs. Cerebrovascular reactivity to hypercapnia improved significantly after preventive treatment (p < 0.001), and the baseline difference in VMR values between the pre-treatment migraine group and the control group was no longer evident at 2 months.

Effetti del topiramato sulla vasoreattività cerebrale valutata mediante Doppler transcranico in pazienti affetti da emicrania con e senz'aura durante il periodo interictale / Ricciardi, MARIA CHIARA. - (2012 May 22).

Effetti del topiramato sulla vasoreattività cerebrale valutata mediante Doppler transcranico in pazienti affetti da emicrania con e senz'aura durante il periodo interictale

RICCIARDI, MARIA CHIARA
22/05/2012

Abstract

Interictal cerebrovascular reactivity to hypercapnia and middle cerebral arteries (MCA) mean flow velocities were investigated in 20 patients with high-frequency migraine (8 with aura and 12 without aura) and 19 age and sex-matched healthy controls by means the CO2 reactivity test. Patients were started on prophylactic treatment with topiramate 100 mg per day, and measurements were repeated after 8 weeks treatment. Baseline mean blood flow velocities were not different in the controls and patients. Cerebrovascular reactivity (VMR), calculated as the percentage increase in MCA velocity during the 90 seconds inhalation of a mixture of 7% CO2/air, was found to be significantly greater (p < 0.01) in both patient groups compared with the controls, showing an exaggerated reactivity to hypercapnia in migraineurs. Cerebrovascular reactivity to hypercapnia improved significantly after preventive treatment (p < 0.001), and the baseline difference in VMR values between the pre-treatment migraine group and the control group was no longer evident at 2 months.
22-mag-2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/918047
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