identification of molecular targets in the human genome

The purpose of the present study is to contribute to the field of functional genomics by developing, testing and applying computational methods to the problem of the evaluation of the effects of environmental and pharmacological molecules on genome expression. Original results are described in four independent sections The first two sections are devoted to the investigation of the coding potential of alternative splicing products in the human genome. Sections three and four are devoted to the application of computational techniques to investigate the molecular targets and the effects on their expression of molecules known to interfere with the physiological functions of a cell. In particular these techniques were applied on a class of compounds (tocotrienols) constituents of the Vitamin E.