BACKGROUND: Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine. METHODS: Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs. RESULTS: After 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P< 0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p < 0.01) habituation during the subsequentblocks. CONCLUSIONS: KD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level.

Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine. A multimodal evoked potentials study / DI LORENZO, Cherubino; Coppola, Gianluca; Bracaglia, Martina; DI LENOLA, Davide; Evangelista, Maurizio; Sirianni, Giulio; Rossi, Paolo; Di Lorenzo, Giorgio; Serrao, Mariano; Parisi, Vincenzo; Pierelli, Francesco. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - ELETTRONICO. - 17:1(2016). [10.1186/s10194-016-0650-9]

Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine. A multimodal evoked potentials study

DI LORENZO, CHERUBINO;COPPOLA, GIANLUCA;BRACAGLIA, MARTINA;DI LENOLA, DAVIDE;ROSSI, Paolo;SERRAO, Mariano;PIERELLI, Francesco
2016

Abstract

BACKGROUND: Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine. METHODS: Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs. RESULTS: After 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P< 0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p < 0.01) habituation during the subsequentblocks. CONCLUSIONS: KD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level.
2016
diet; habituation; ketogenesis; migraine; somatosensory-evoked potentials; visual-evoked potentials; adult; cerebral cortex; evoked potentials, auditory; evoked potentials, somatosensory; evoked potentials, visual; female; habituation, psychophysiologic; humans; male; middle aged; migraine disorders; evoked potentials; ketogenic diet; anesthesiology and pain medicine; neurology (clinical)
01 Pubblicazione su rivista::01a Articolo in rivista
Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine. A multimodal evoked potentials study / DI LORENZO, Cherubino; Coppola, Gianluca; Bracaglia, Martina; DI LENOLA, Davide; Evangelista, Maurizio; Sirianni, Giulio; Rossi, Paolo; Di Lorenzo, Giorgio; Serrao, Mariano; Parisi, Vincenzo; Pierelli, Francesco. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - ELETTRONICO. - 17:1(2016). [10.1186/s10194-016-0650-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/912923
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