The 3Ks (kava, kratom and khat) are herbals that can potentially induce liver injuries. On the one hand, growing controversial data have been reported about the hepatotoxicity of kratom, while, on the other hand, even though kava and khat hepatotoxicity has been investigated, the hepatotoxic effects are still not clear. Chronic recreational use of kratom has been associated with rare instances of acute liver injury. Several studies and case reports have suggested that khat is hepatotoxic, leading to deranged liver enzymes and also histopathological evidence of acute hepatocellular degeneration. Numerous reports of severe hepatotoxicity potentially induced by kava have also been highlighted, both in the USA and Europe. The aim of this review is to focus on the different patterns and the mechanisms of hepatotoxicity induced by "the 3Ks", while trying to clarify the numerous aspects that still need to be addressed.

Hepatotoxicity induced by “the 3Ks”: kava, kratom and khat / Pantano, F; Tittarelli, R; Mannocchi, G; Zaami, S; Ricci, S; Giorgetti, R; Terranova, D; Busardò, Fp; Marinelli, E.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 17:4(2016), pp. 1-30. [10.3390/ijms17040580]

Hepatotoxicity induced by “the 3Ks”: kava, kratom and khat

Pantano, F;Tittarelli, R;Mannocchi, G;Zaami, S;Ricci, S;Terranova, D;Busardò, Fp
;
Marinelli, E.
2016

Abstract

The 3Ks (kava, kratom and khat) are herbals that can potentially induce liver injuries. On the one hand, growing controversial data have been reported about the hepatotoxicity of kratom, while, on the other hand, even though kava and khat hepatotoxicity has been investigated, the hepatotoxic effects are still not clear. Chronic recreational use of kratom has been associated with rare instances of acute liver injury. Several studies and case reports have suggested that khat is hepatotoxic, leading to deranged liver enzymes and also histopathological evidence of acute hepatocellular degeneration. Numerous reports of severe hepatotoxicity potentially induced by kava have also been highlighted, both in the USA and Europe. The aim of this review is to focus on the different patterns and the mechanisms of hepatotoxicity induced by "the 3Ks", while trying to clarify the numerous aspects that still need to be addressed.
hepatotoxicity; herb induced liver injury; herbals; kava; khat; kratom
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatotoxicity induced by “the 3Ks”: kava, kratom and khat / Pantano, F; Tittarelli, R; Mannocchi, G; Zaami, S; Ricci, S; Giorgetti, R; Terranova, D; Busardò, Fp; Marinelli, E.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 17:4(2016), pp. 1-30. [10.3390/ijms17040580]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/912891
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