Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long-term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this activity

Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants / Malaviya, R; Sunil, Vr; Venosa, A; Vayas, Kn; Businaro, Rita; Heck, De; Laskin, Jd; Laskin, D. l.. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - STAMPA. - 1374:1(2016), pp. 168-175. [10.1111/nyas.13123]

Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants

BUSINARO, Rita;
2016

Abstract

Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long-term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this activity
2016
mustards; pulmonary toxicity; macrophages; inflammatory mediators
01 Pubblicazione su rivista::01a Articolo in rivista
Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants / Malaviya, R; Sunil, Vr; Venosa, A; Vayas, Kn; Businaro, Rita; Heck, De; Laskin, Jd; Laskin, D. l.. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - STAMPA. - 1374:1(2016), pp. 168-175. [10.1111/nyas.13123]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/912656
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