Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.
PARK11 is not linked with Parkinson's disease in European families / Jurgen, P., Manu, S., Petra, L., Alexander, Z., Jenny R., V., Alexandra, D., Bonifati, V., Giuseppe De, M., Hasmet A., H., Matthew, F., Anne, H., Friedrich, A., Giampiero, V., Meco, G., Alexis, B., Nicholas W., W., Bertram Muller, M., Thomas, G., I. N., P.D.G.E.C.O.G.S.. - In: EUROPEAN JOURNAL OF HUMAN GENETICS. - ISSN 1018-4813. - 13:2(2005), pp. 193-197. [10.1038/sj.ejhg.5201317]
PARK11 is not linked with Parkinson's disease in European families
BONIFATI, Vincenzo;MECO, Giuseppe;
2005
Abstract
Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
