Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.
PARK11 is not linked with Parkinson's disease in European families / Jurgen, Prestel; Manu, Sharma; Petra, Leitner; Alexander, Zimprich; Jenny R., Vaughan; Alexandra, Durr; Bonifati, Vincenzo; Giuseppe De, Michele; Hasmet A., Hanagasi; Matthew, Farrer; Anne, Hofer; Friedrich, Asmus; Giampiero, Volpe; Meco, Giuseppe; Alexis, Brice; Nicholas W., Wood; Bertram Muller, Myhsok; Thomas, Gasser; I. N., Parkinson'S Disease Gspd European Consortium On Genetic Susceptibility. - In: EUROPEAN JOURNAL OF HUMAN GENETICS. - ISSN 1018-4813. - 13:2(2005), pp. 193-197. [10.1038/sj.ejhg.5201317]
PARK11 is not linked with Parkinson's disease in European families
BONIFATI, Vincenzo;MECO, Giuseppe;
2005
Abstract
Parkinson's disease (PD) is a genetically heterogeneous disease. Recently, significant linkage has been reported to a 39.5 cM region on the long arm of chromosome 2 (2q36-37; PARK11) in North American Parkinson families under an autosomal dominant model of inheritance. We have performed a replication study to confirm linkage to this region in a European population. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. Therefore, PARK11 does not seem to play a major role for familial PD in the European population.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
