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BACKGROUND: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe. METHODS: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ(2) and Fisher's exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p<0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries. FINDINGS: We included 46,539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9-3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0-3·0] for Iceland to 21·5% [16·9-26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19-1·05; p=0·06] for Finland to 6·92 [2·37-20·27; p=0·0004] for Poland). INTERPRETATION: The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients. FUNDING: European Society of Intensive Care Medicine, European Society of Anaesthesiology.

Mortality after surgery in Europe: A 7 day cohort study / Pearse, R., Moreno, R.P., Bauer, P., Pelosi, P., Metnitz, P., Spies, C., Vallet, B., Vincent, J.L., Hoeft, A., Rhodes, A., Fagnoul, D., van Obbergh, L., Al Subaie, N., Arif, F., Cashman, J., Cecconi, M., Edsell, M., Fossati, N., Hammond, S.J., Hamilton, M., et al.. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 380:9847(2012), pp. 1059-1065. [10.1016/S0140-6736(12)61148-9]

Mortality after surgery in Europe: A 7 day cohort study

ALBANTE, ALIDA;LOIACONO, CINZIA;MARANDOLA, Maurizio;PUGLIESE, Francesco;Ruberto, Franco;RANIERI, VITO MARCO;
2012

Abstract

BACKGROUND: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe. METHODS: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ(2) and Fisher's exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p<0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries. FINDINGS: We included 46,539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9-3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0-3·0] for Iceland to 21·5% [16·9-26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19-1·05; p=0·06] for Finland to 6·92 [2·37-20·27; p=0·0004] for Poland). INTERPRETATION: The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients. FUNDING: European Society of Intensive Care Medicine, European Society of Anaesthesiology.
2012
Medicine (all)
01 Pubblicazione su rivista::01a Articolo in rivista
Mortality after surgery in Europe: A 7 day cohort study / Pearse, R., Moreno, R.P., Bauer, P., Pelosi, P., Metnitz, P., Spies, C., Vallet, B., Vincent, J.L., Hoeft, A., Rhodes, A., Fagnoul, D., van Obbergh, L., Al Subaie, N., Arif, F., Cashman, J., Cecconi, M., Edsell, M., Fossati, N., Hammond, S.J., Hamilton, M., et al.. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 380:9847(2012), pp. 1059-1065. [10.1016/S0140-6736(12)61148-9]
01a Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/911387
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