Dear Editor, We would like to make some considerations regarding the recent review of Cecchi R [1]. entitled: ‘‘Diagnosis of anaphylactic death in forensics: Review and future perspectives”. In the manuscript the Author addresses some important issues regarding various problems still to be resolved in international scientific literature, because of the diverse and complicated pathogenic factors and the pathophysiological processes which characterize the diagnosis of anaphylaxis both in ante and postmortem stages [1]. After a comprehensive excursus on microscopic findings which can be detected in anaphylactic-related deaths, focusing especially on aspects linked to differential diagnosis and possible applications of immunohistochemistry for the detection of mast cells in tissues (e.g. in cutis and perivascular tissues and in bronchial, respiratory and intestinal mucosa) by anti-tryptase and anti-chymase antibodies, the Author highlights the importance of some analytical techniques which are able to detect and quantify in biological fluids, the mediators released by mast cells and basophils implicated in the type I hypersensitivity reaction
Is the diagnosis of anaphylaxis reliable in forensics? The role of β-tryptase and its correct interpretation / Busardo', FRANCESCO PAOLO; Marinelli, Enrico; Zaami, Simona. - In: LEGAL MEDICINE. - ISSN 1344-6223. - 23:(2016), pp. 86-88. [10.1016/j.legalmed.2016.10.005]
Is the diagnosis of anaphylaxis reliable in forensics? The role of β-tryptase and its correct interpretation
BUSARDO', FRANCESCO PAOLOPrimo
;MARINELLI, Enrico
Secondo
;ZAAMI, SimonaUltimo
2016
Abstract
Dear Editor, We would like to make some considerations regarding the recent review of Cecchi R [1]. entitled: ‘‘Diagnosis of anaphylactic death in forensics: Review and future perspectives”. In the manuscript the Author addresses some important issues regarding various problems still to be resolved in international scientific literature, because of the diverse and complicated pathogenic factors and the pathophysiological processes which characterize the diagnosis of anaphylaxis both in ante and postmortem stages [1]. After a comprehensive excursus on microscopic findings which can be detected in anaphylactic-related deaths, focusing especially on aspects linked to differential diagnosis and possible applications of immunohistochemistry for the detection of mast cells in tissues (e.g. in cutis and perivascular tissues and in bronchial, respiratory and intestinal mucosa) by anti-tryptase and anti-chymase antibodies, the Author highlights the importance of some analytical techniques which are able to detect and quantify in biological fluids, the mediators released by mast cells and basophils implicated in the type I hypersensitivity reactionFile | Dimensione | Formato | |
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