BCVA changes after suprachoroideal graft of autologous cells in Dry AMD

The idea of cell therapy using the systemic or local injection of stem/progenitor cells in the area of injury to treat multiple chronic disorders received close attention in the last decade. Our prior study showed in eyes affected by Dry AMD a significant improvement of ERG data, recorded after the suprachoroidal autologous graft. Dry AMD is an atrophic retinal disease where the cells die progressively and irreversibly with a loss of central visual function. From the choroid the growth factors could arrive at the retinal cells. Their interaction with membrane receptors of retinal cells can activate an intracellular pathway. Consequently, we can have in the cell nucleus genic responses. We can obtain an antiapoptotic effect which can explain the neuroenhancement. This suggests a greater potential increase of BCVA in the grafted group.