Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.

Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ- plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.

Sexually dimorphic expression of reelin in the brain of a mouse model of Alzheimer disease / Palladino, Giampiero; Nicolia, Vincenzina; Kovacs, Gg; Canterini, Sonia; Ciraci, Viviana; Fuso, Andrea; Mangia, F; Scarpa, S; Fiorenza, Maria Teresa. - In: JOURNAL OF MOLECULAR NEUROSCIENCE. - ISSN 0895-8696. - STAMPA. - 61:(2017), pp. 359-367. [DOI 10.1007/s12031-016-0865-x]

Sexually dimorphic expression of reelin in the brain of a mouse model of Alzheimer disease

PALLADINO, GIAMPIERO;NICOLIA, Vincenzina;CANTERINI, Sonia;CIRACI, VIVIANA;FUSO, ANDREA;FIORENZA, Maria Teresa
2017

Abstract

Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
2017
Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ- plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
TgCRND8; mouse models ofAD; sex-influenced gene expression patterns,;Aβ-plaques
01 Pubblicazione su rivista::01a Articolo in rivista
Sexually dimorphic expression of reelin in the brain of a mouse model of Alzheimer disease / Palladino, Giampiero; Nicolia, Vincenzina; Kovacs, Gg; Canterini, Sonia; Ciraci, Viviana; Fuso, Andrea; Mangia, F; Scarpa, S; Fiorenza, Maria Teresa. - In: JOURNAL OF MOLECULAR NEUROSCIENCE. - ISSN 0895-8696. - STAMPA. - 61:(2017), pp. 359-367. [DOI 10.1007/s12031-016-0865-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/908476
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