Introduction: Endometrial cancer (EC) is the most common gynaecological cancer. Despite significant progress in the multimodality treatment approach, the prognosis remains poor for patients with advanced disease. Thus, there is the necessity of more effective strategies. The microtubule-stabilizing agent ixabepilone is the first drug in this new class of agents that has been approved for metastatic breast cancer treatment. Based on empiric data and on the clinical efficacy demonstrated in breast cancer, several clinical trials were proposed to define its role in EC. The aim of this review is to determine whether ixabepilone improved the clinical outcome in patients with locally advanced, recurrent or metastatic EC. Areas covered: Preclinical and clinical studies of ixabepilone in endometrial cancer were analyzed and discussed. Data were obtained by searching for English peer-reviewed articles on PubMed, phase I and II studies registered on clincaltrials.gov, and related abstracts recently presented at major international congresses. Expert opinion: Advanced or recurrent EC still represents a challenge and an unmet need in the panorama of gynaecological malignancies. Ixabepilone’s future therapeutic role in EC remains ill defined. Nevertheless, despite its limited efficacy in EC, clinicians treating gynaecological tumours should be aware of its main aspects.

Ixabepilone for the treatment of endometrial cancer / Marchetti, Claudia; Piacenti, Ilaria; Imperiale, Ludovica; DE FELICE, Francesca; Boccia, SERENA MARIA; DI DONATO, Violante; Perniola, Giorgia; Monti, Marco; Palaia, Innocenza; Muzii, Ludovico; BENEDETTI PANICI, Pierluigi. - In: EXPERT OPINION ON INVESTIGATIONAL DRUGS. - ISSN 1354-3784. - STAMPA. - 25:5(2016), pp. 613-618. [10.1517/13543784.2016.1161755]

Ixabepilone for the treatment of endometrial cancer

MARCHETTI, CLAUDIA
Primo
;
PIACENTI, ILARIA
Secondo
;
IMPERIALE, LUDOVICA;DE FELICE, FRANCESCA;BOCCIA, SERENA MARIA;DI DONATO, VIOLANTE;PERNIOLA, GIORGIA;MONTI, Marco;PALAIA, INNOCENZA;MUZII, LUDOVICO
Penultimo
;
BENEDETTI PANICI, PIERLUIGI
Ultimo
2016

Abstract

Introduction: Endometrial cancer (EC) is the most common gynaecological cancer. Despite significant progress in the multimodality treatment approach, the prognosis remains poor for patients with advanced disease. Thus, there is the necessity of more effective strategies. The microtubule-stabilizing agent ixabepilone is the first drug in this new class of agents that has been approved for metastatic breast cancer treatment. Based on empiric data and on the clinical efficacy demonstrated in breast cancer, several clinical trials were proposed to define its role in EC. The aim of this review is to determine whether ixabepilone improved the clinical outcome in patients with locally advanced, recurrent or metastatic EC. Areas covered: Preclinical and clinical studies of ixabepilone in endometrial cancer were analyzed and discussed. Data were obtained by searching for English peer-reviewed articles on PubMed, phase I and II studies registered on clincaltrials.gov, and related abstracts recently presented at major international congresses. Expert opinion: Advanced or recurrent EC still represents a challenge and an unmet need in the panorama of gynaecological malignancies. Ixabepilone’s future therapeutic role in EC remains ill defined. Nevertheless, despite its limited efficacy in EC, clinicians treating gynaecological tumours should be aware of its main aspects.
2016
chemotherapy; endometrial cancer; epothilones; ixabepilone; metastatic; new agents; recurrent disease; pharmacology; pharmacology (medical)
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Ixabepilone for the treatment of endometrial cancer / Marchetti, Claudia; Piacenti, Ilaria; Imperiale, Ludovica; DE FELICE, Francesca; Boccia, SERENA MARIA; DI DONATO, Violante; Perniola, Giorgia; Monti, Marco; Palaia, Innocenza; Muzii, Ludovico; BENEDETTI PANICI, Pierluigi. - In: EXPERT OPINION ON INVESTIGATIONAL DRUGS. - ISSN 1354-3784. - STAMPA. - 25:5(2016), pp. 613-618. [10.1517/13543784.2016.1161755]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/906303
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