Antibiotic resistance of bacteria growing in biofilms compared to their planktonic counterparts enhances the difficulty to eradicate biofilm-associated infections. In the last decade, combination antibiotic therapy has emerged as an attractive strategy for treating biofilm infections, even if in most of tolerant biofilms the optimal combinations are still unknown. In this study, an antimicrobial cationic polyacrylamide was used in combination with daptomycin or moxifloxacin against mature biofilms of Staphylococcus aureus clinical isolates to examine a possible improvement of the antibiofilm activity of the two antibiotics. The polymer did not have an effect on moxifloxacin but significantly increased the antibiofilm efficacy of daptomycin. These findings are presumably related to the different mechanism of action of the two drugs. In summary, our data highlighted the ability of polycations to increase daptomycin antibiofilm activity providing a potential strategy to eradicate biofilms in industrial or medical settings.

Synergistic activity between an antimicrobial polyacrylamide and daptomycin versus Staphylococcus aureus biofilm / Siala, W.; Van Bambeke, F.; Taresco, V.; Piozzi, Antonella; Francolini, Iolanda. - In: PATHOGENS AND DISEASE. - ISSN 2049-632X. - STAMPA. - 74:5(2016). [10.1093/femspd/ftw042]

Synergistic activity between an antimicrobial polyacrylamide and daptomycin versus Staphylococcus aureus biofilm

PIOZZI, Antonella;FRANCOLINI, IOLANDA
2016

Abstract

Antibiotic resistance of bacteria growing in biofilms compared to their planktonic counterparts enhances the difficulty to eradicate biofilm-associated infections. In the last decade, combination antibiotic therapy has emerged as an attractive strategy for treating biofilm infections, even if in most of tolerant biofilms the optimal combinations are still unknown. In this study, an antimicrobial cationic polyacrylamide was used in combination with daptomycin or moxifloxacin against mature biofilms of Staphylococcus aureus clinical isolates to examine a possible improvement of the antibiofilm activity of the two antibiotics. The polymer did not have an effect on moxifloxacin but significantly increased the antibiofilm efficacy of daptomycin. These findings are presumably related to the different mechanism of action of the two drugs. In summary, our data highlighted the ability of polycations to increase daptomycin antibiofilm activity providing a potential strategy to eradicate biofilms in industrial or medical settings.
2016
antimicrobial polymers; Daptomycin; microbial biofilm; polycations; polyacrylamides
01 Pubblicazione su rivista::01a Articolo in rivista
Synergistic activity between an antimicrobial polyacrylamide and daptomycin versus Staphylococcus aureus biofilm / Siala, W.; Van Bambeke, F.; Taresco, V.; Piozzi, Antonella; Francolini, Iolanda. - In: PATHOGENS AND DISEASE. - ISSN 2049-632X. - STAMPA. - 74:5(2016). [10.1093/femspd/ftw042]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/905295
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