On account of the lack of predictive biomarkers of toxicity, we investigated whether polymorphisms of genes involved in fluoropyrimidine metabolism and 5-fluorouracil (5-FU) degradation rate were associated with outcomes of adjuvant capecitabine in patients with early stage gastrointestinal cancers.
Evaluation of 5-fluorouracil degradation rate and pharmacogenetic profiling to predict toxicity following adjuvant capecitabine / Roberto, Michela; Romiti, Adriana; Botticelli, Andrea; Mazzuca, Federica; Lionetto, Luana; Gentile, Giovanna; Paris, Ida; Falcone, Rosa; Bassanelli, Maria; DI PIETRO, FRANCESCA ROMANA; Onesti, CONCETTA ELISA; Anselmi, Elisabetta; Macrini, Serena; Simmaco, Maurizio; Marchetti, Paolo. - In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0031-6970. - STAMPA. - 73:2(2017), pp. 157-164. [10.1007/s00228-016-2160-8]
Evaluation of 5-fluorouracil degradation rate and pharmacogenetic profiling to predict toxicity following adjuvant capecitabine
ROBERTO, MICHELA;ROMITI, ADRIANA;BOTTICELLI, ANDREA;MAZZUCA, FEDERICA;GENTILE, Giovanna;FALCONE, ROSA;BASSANELLI, MARIA;DI PIETRO, FRANCESCA ROMANA;ONESTI, CONCETTA ELISA;ANSELMI, ELISABETTA;MACRINI, SERENA;SIMMACO, Maurizio;MARCHETTI, PAOLO
2017
Abstract
On account of the lack of predictive biomarkers of toxicity, we investigated whether polymorphisms of genes involved in fluoropyrimidine metabolism and 5-fluorouracil (5-FU) degradation rate were associated with outcomes of adjuvant capecitabine in patients with early stage gastrointestinal cancers.| File | Dimensione | Formato | |
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