A therapeutically challenging subset of cells, termed cancer stem cells (CSCs) are responsible for cholangiocarcinoma (CCA) clinical severity. Presence of tumor-associated macrophages (TAMs) has prognostic significance in CCA and other malignancies. Thus, we hypothesized that CSCs may actively shape their tumor-supportive immune niche.
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages / Raggi, Chiara; Correnti, Margherita; Sica, Antonio; Andersen, Jesper B; Cardinale, Vincenzo; Alvaro, Domenico; Chiorino, Giovanna; Forti, Elisa; Glaser, Shannon; Alpini, Gianfranco; Destro, Annarita; Sozio, Francesca; Di Tommaso, Luca; Roncalli, Massimo; Banales, Jesus M; Coulouarn, Cédric; Bujanda, Luis; Torzilli, Guido; Invernizzi, Pietro. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 66:1(2016), pp. 102-115. [10.1016/j.jhep.2016.08.012]
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages
CARDINALE, VINCENZO;ALVARO, Domenico;Sozio, Francesca;
2016
Abstract
A therapeutically challenging subset of cells, termed cancer stem cells (CSCs) are responsible for cholangiocarcinoma (CCA) clinical severity. Presence of tumor-associated macrophages (TAMs) has prognostic significance in CCA and other malignancies. Thus, we hypothesized that CSCs may actively shape their tumor-supportive immune niche.| File | Dimensione | Formato | |
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