A therapeutically challenging subset of cells, termed cancer stem cells (CSCs) are responsible for cholangiocarcinoma (CCA) clinical severity. Presence of tumor-associated macrophages (TAMs) has prognostic significance in CCA and other malignancies. Thus, we hypothesized that CSCs may actively shape their tumor-supportive immune niche.
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages / Raggi, C., Correnti, M., Sica, A., Andersen, J.B., Cardinale, V., Alvaro, D., Chiorino, G., Forti, E., Glaser, S., Alpini, G., Destro, A., Sozio, F., Di Tommaso, L., Roncalli, M., Banales, J.M., Coulouarn, C., Bujanda, L., Torzilli, G., Invernizzi, P.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 66:1(2016), pp. 102-115. [10.1016/j.jhep.2016.08.012]
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages
CARDINALE, VINCENZO;ALVARO, Domenico;Sozio, Francesca;
2016
Abstract
A therapeutically challenging subset of cells, termed cancer stem cells (CSCs) are responsible for cholangiocarcinoma (CCA) clinical severity. Presence of tumor-associated macrophages (TAMs) has prognostic significance in CCA and other malignancies. Thus, we hypothesized that CSCs may actively shape their tumor-supportive immune niche.| File | Dimensione | Formato | |
|---|---|---|---|
|
Raggi_stem-like_2016.pdf
solo gestori archivio
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
3.44 MB
Formato
Adobe PDF
|
3.44 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
