The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.
Construction of the 1,5-benzodiazepine skeleton from o-phenylendiamine and propargylic alcohols via a domino gold-catalyzed hydroamination/cyclization process / Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Iazzetti, Antonia. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 18:15(2016), pp. 3511-3513. [10.1021/acs.orglett.6b01720]
Construction of the 1,5-benzodiazepine skeleton from o-phenylendiamine and propargylic alcohols via a domino gold-catalyzed hydroamination/cyclization process
CACCHI, Sandro;FABRIZI, Giancarlo;GOGGIAMANI, ANTONELLA
;IAZZETTI, Antonia
2016
Abstract
The gold-catalyzed reaction of o-phenylendiamine with propargylic alcohols affords 1,5-benzodiazepines bearing different substituents on the 2 and 4 positions. The method allows even for the selective preparation of 4-substituted 1,5-benzodiazepine derivatives.File allegati a questo prodotto
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