The effects on metabolism by a synthetic corticosteroid drug, clobetasone-17-butyrate, were investigated in rabbit lenses by P-31, H-1, C-13 nuclear magnetic resonance spectroscopy. No variations were observed in the levels of sorbitol, sorbitol 3-P, alpha-glycerophosphate, fructose 3-P or myoinositol. Moreover, clobetasone-17-butyrate was not shown to influence the active transport of amino acids nor to alter blood sugar levels. These results indicate that clobetasone-17-butyrate instillation does not induce side effects in the rabbit lens, as has been reported following dexamethasone treatment.
CLOBETASONE-17-BUTYRATE AND CATARACT P-13, H-1, C-13 NMR-STUDY / Pescosolido, Nicola; M., Accorinti; Delfini, Maurizio; F., Guglielmelli; M., Lazzari; Manetti, Cesare; Miccheli, Alfredo. - In: DRUG INVESTIGATION. - ISSN 0114-2402. - STAMPA. - 6:2(1993), pp. 83-89. [10.1007/bf03258457]
CLOBETASONE-17-BUTYRATE AND CATARACT P-13, H-1, C-13 NMR-STUDY
PESCOSOLIDO, Nicola;DELFINI, Maurizio;MANETTI, Cesare;MICCHELI, Alfredo
1993
Abstract
The effects on metabolism by a synthetic corticosteroid drug, clobetasone-17-butyrate, were investigated in rabbit lenses by P-31, H-1, C-13 nuclear magnetic resonance spectroscopy. No variations were observed in the levels of sorbitol, sorbitol 3-P, alpha-glycerophosphate, fructose 3-P or myoinositol. Moreover, clobetasone-17-butyrate was not shown to influence the active transport of amino acids nor to alter blood sugar levels. These results indicate that clobetasone-17-butyrate instillation does not induce side effects in the rabbit lens, as has been reported following dexamethasone treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
