Abstract Background: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. Aim: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. Patients: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. Results: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P < 0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P = 0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P < 0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery). Conclusions: The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.

Abstract Background: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. Aim: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. Patients: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. Results: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P < 0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P = 0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P < 0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery). Conclusions: The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.

A prospective multicentre survey on the treatment of acute pancreatitis in Italy / Pezzilli, R; Uomo, G.; Gabbrielli, A.; Zerbi, A.; Frulloni, L.; De Rai, P.; Castoldi, L.; Cavallini, G.; Di Carlo, V.; Agugiaro, S.; Turri, L.; Bartoli, A.; Barberini, F.; Cavazoni, G.; Bartolo, F.; Della Papa, D.; Bassi, C.; Bassi, N.; Massani, M.; Benedetti, A.; Macarri, G.; Piergallini, L.; Briani, G.; Bartolasi, L.; Brugnano, L.; Buonanno, G. M.; Esposito, C.; Cardovana, A.; Cavina, E.; Seccia, M.; Lipollis, P.; Musco, B.; Barletta, M.; Chilovi, E.; De Guelmi, A.; Chirletti, Piero; Caronna, Roberto; Scozzafava, S.; Cardi, Maurizio; Cirino, E.; Buffone, A.; Colangelo, E.; Caracino, V.; Cortese, F.; Cosentini, A.; Costamagna, G.; Tringali, A.; Curzio, M.; Clivio, S.; Segato, S.; D'Alessandro, A.; Ambrosini, V.; D'Amborsio, B.; Chiodo, C.; Dicillo, M.; Reale, L.; Grandolfo, A.; Fabbrucci, P.; Bruscino, A.; Mugnaini, P.; Ferrarese, S.; Ugenti, I.; Forte, G. B.; Rocco, P.; Franzè, A.; Bertelè, A.; Sereni, G.; Friedman, D.; Mariani, L. M.; Murelli, F.; Gai, V.; Antro, C.; Garcea, D.; Gardini, A.; Lucci, E.; Giulianotti, P. C.; Sbrana, F.; Balestracci, T.; Giulini, S. M.; Pellizzari, A.; Ronconi, M.; Cimaschi, S.; Grassini, M.; Lacitignola, S.; Caliandro, L.; Mazzitelli, R.; Costarella, S. M.; Egidio, A.; Mello Teggia, P.; Stefano, E.; Cassini, P.; Modica, G.; Lupo, F.; Giraci, G.; Mosca, F.; Del Chiaro, M.; Mosella, G.; Benassai, G.; Nanni, M.; D'Aristotile, A.; Negro, P.; Pirazzoli, A.; Rabitti, P. G.; Romano, C.; Gerardi, G.; Troianello, B.; Russello, D.; Di Stefano, A.; Avelli, S.; Salvai, M.; Bellini, N.; Scalon, P.; Staudacher, C.; Parolini, D.; Strazzabosco, M.; Signorelli, S.; Tedeschi, U.; Testoni, P. A.; Masci, E.; Mariani, A.; Torelli, E.; Garcea, M. R.; Lombardi, V.; Cecconi, L.; Valeri, A.; Presenti, L.; Alessio, F.; Ventrucci, M.; Virzi, S.; Cipolla, A.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - ELETTRONICO. - 39:9(2007), pp. 838-846. [10.1016/j.dld.2007.05.014]

A prospective multicentre survey on the treatment of acute pancreatitis in Italy

CHIRLETTI, Piero;CARONNA, Roberto;CARDI, Maurizio;
2007

Abstract

Abstract Background: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. Aim: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. Patients: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. Results: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P < 0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P = 0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P < 0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery). Conclusions: The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.
2007
Abstract Background: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. Aim: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. Patients: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. Results: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P < 0.001). Gabexate mesilate was utilised in 831 out of 1173 patients (70.8%); in particular, gabexate mesilate was used in 70.6% patients with MAP and in 73.1% of those with SAP (P = 0.521). The duration of the drug administration was significantly shorter in those having MAP than in those having the SAP (P < 0.001). The antibiotics most frequently used for the prophylaxis against infection from pancreatic necrosis (43.1%) were carbapenems. Only a small number of patients received enteral nutrition (4.7%). Endoscopic retrograde cholangiopancreatography was carried out in 344 of the 1173 patients (29.3%). Surgery was performed in 48 with SAP (19 had elective biliary surgery and 29 had pancreatic surgery). Conclusions: The results of this survey indicate a lack of compliance with the guidelines which regard the indications mainly for interventional endoscopy and surgery.
ERCP; Pancreatitis; Pancreatitis acute necrotising; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Bacterial Agents; Digestive System Surgical Procedures; Female; Histamine Antagonists; Humans; Italy; Male; Middle Aged; Pancreatitis; Prospective Studies; Severity of Illness Index; Treatment Outcome; Medicine (all); Hepatology; Gastroenterology
01 Pubblicazione su rivista::01a Articolo in rivista
A prospective multicentre survey on the treatment of acute pancreatitis in Italy / Pezzilli, R; Uomo, G.; Gabbrielli, A.; Zerbi, A.; Frulloni, L.; De Rai, P.; Castoldi, L.; Cavallini, G.; Di Carlo, V.; Agugiaro, S.; Turri, L.; Bartoli, A.; Barberini, F.; Cavazoni, G.; Bartolo, F.; Della Papa, D.; Bassi, C.; Bassi, N.; Massani, M.; Benedetti, A.; Macarri, G.; Piergallini, L.; Briani, G.; Bartolasi, L.; Brugnano, L.; Buonanno, G. M.; Esposito, C.; Cardovana, A.; Cavina, E.; Seccia, M.; Lipollis, P.; Musco, B.; Barletta, M.; Chilovi, E.; De Guelmi, A.; Chirletti, Piero; Caronna, Roberto; Scozzafava, S.; Cardi, Maurizio; Cirino, E.; Buffone, A.; Colangelo, E.; Caracino, V.; Cortese, F.; Cosentini, A.; Costamagna, G.; Tringali, A.; Curzio, M.; Clivio, S.; Segato, S.; D'Alessandro, A.; Ambrosini, V.; D'Amborsio, B.; Chiodo, C.; Dicillo, M.; Reale, L.; Grandolfo, A.; Fabbrucci, P.; Bruscino, A.; Mugnaini, P.; Ferrarese, S.; Ugenti, I.; Forte, G. B.; Rocco, P.; Franzè, A.; Bertelè, A.; Sereni, G.; Friedman, D.; Mariani, L. M.; Murelli, F.; Gai, V.; Antro, C.; Garcea, D.; Gardini, A.; Lucci, E.; Giulianotti, P. C.; Sbrana, F.; Balestracci, T.; Giulini, S. M.; Pellizzari, A.; Ronconi, M.; Cimaschi, S.; Grassini, M.; Lacitignola, S.; Caliandro, L.; Mazzitelli, R.; Costarella, S. M.; Egidio, A.; Mello Teggia, P.; Stefano, E.; Cassini, P.; Modica, G.; Lupo, F.; Giraci, G.; Mosca, F.; Del Chiaro, M.; Mosella, G.; Benassai, G.; Nanni, M.; D'Aristotile, A.; Negro, P.; Pirazzoli, A.; Rabitti, P. G.; Romano, C.; Gerardi, G.; Troianello, B.; Russello, D.; Di Stefano, A.; Avelli, S.; Salvai, M.; Bellini, N.; Scalon, P.; Staudacher, C.; Parolini, D.; Strazzabosco, M.; Signorelli, S.; Tedeschi, U.; Testoni, P. A.; Masci, E.; Mariani, A.; Torelli, E.; Garcea, M. R.; Lombardi, V.; Cecconi, L.; Valeri, A.; Presenti, L.; Alessio, F.; Ventrucci, M.; Virzi, S.; Cipolla, A.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - ELETTRONICO. - 39:9(2007), pp. 838-846. [10.1016/j.dld.2007.05.014]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/902229
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