Bevacizumab (BV) is a humanized monoclonal antibody targeting vascular endothelial growth factor and it is the first molecular-targeted agent to be used for the treatment of ovarian cancer (OC). Randomized Phase III trials evaluated the combination of BV plus standard chemotherapy for first-line treatment of advanced OC and for platinum-sensitive and platinum-resistant recurrent OC. These trials reported a statistically significant improvement in progression-free survival but not in overall survival. Furthermore, BV effectively improved the quality of life with regard to abdominal symptoms in recurrent OC patients. Bevacizumab is associated with adverse events such as hypertension, bleeding, thromboembolism, proteinuria, delayed wound healing, and gastrointestinal events. However, most of these events can be adequately managed. This review describes the latest evidence for BV treatment of OC and selection of patients for personalized treatment.

Bevacizumab in ovarian cancer: A critical review of phase III studies / Rossi, Luigi; Verrico, Monica; Zaccarelli, Eleonora; Papa, Anselmo; Colonna, Maria; Strudel, Martina; Vici, Patrizia; Bianco, Vincenzo; Tomao, Federica. - In: ONCOTARGET. - ISSN 1949-2553. - STAMPA. - (2016). [10.18632/oncotarget.13310]

Bevacizumab in ovarian cancer: A critical review of phase III studies

ROSSI, Luigi;VERRICO, MONICA;ZACCARELLI, ELEONORA;PAPA, ANSELMO;COLONNA, MARIA;STRUDEL, MARTINA;BIANCO, VINCENZO;TOMAO, FEDERICA
2016

Abstract

Bevacizumab (BV) is a humanized monoclonal antibody targeting vascular endothelial growth factor and it is the first molecular-targeted agent to be used for the treatment of ovarian cancer (OC). Randomized Phase III trials evaluated the combination of BV plus standard chemotherapy for first-line treatment of advanced OC and for platinum-sensitive and platinum-resistant recurrent OC. These trials reported a statistically significant improvement in progression-free survival but not in overall survival. Furthermore, BV effectively improved the quality of life with regard to abdominal symptoms in recurrent OC patients. Bevacizumab is associated with adverse events such as hypertension, bleeding, thromboembolism, proteinuria, delayed wound healing, and gastrointestinal events. However, most of these events can be adequately managed. This review describes the latest evidence for BV treatment of OC and selection of patients for personalized treatment.
anti-angiogenic therapy; bevacizumab; biological therapy; chemotherapy; ovarian cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Bevacizumab in ovarian cancer: A critical review of phase III studies / Rossi, Luigi; Verrico, Monica; Zaccarelli, Eleonora; Papa, Anselmo; Colonna, Maria; Strudel, Martina; Vici, Patrizia; Bianco, Vincenzo; Tomao, Federica. - In: ONCOTARGET. - ISSN 1949-2553. - STAMPA. - (2016). [10.18632/oncotarget.13310]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/901830
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