The study of the expression of CD16, CD11b and Siglec 9 receptors and the oxidative burst provides insights on polymorphonuclear leukocytes (PMN) functionality in common variable immunodeficiency (CVID) and on the possible effects of intravenous immunoglobulin (IVIg) infusion. We evaluated in vivo before and soon after IVIg administration the CD16, CD11b and Siglec 9 expression on unstimulated and Escherichia coli-stimulated PMN and the oxidative burst induced by Escherichia coli and PMA. The E. coli stimulation up-regulated CD16 and Siglec 9 expression and it induced a strong CD11b up-regulation at baseline and soon after IVIg. The oxidative burst overlapped that observed in healthy donors when induced by Escherichia coli while it increased when induced by PMA. Soon after IVIg infusion, the oxidative burst decreased only when induced by PMA. Our results showed that the IVIg infusion in vivo had a minimal effect on CVID's PMN

Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency / Prezzo, Alessandro; Cavaliere, Filomena Monica; Bilotta, C; Iacobini, Metello; Quinti, Isabella. - In: CELLULAR IMMUNOLOGY. - ISSN 0008-8749. - ELETTRONICO. - 307:306(2016), pp. 25-34. [10.1016/j.cellimm.2016.05.006]

Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency

PREZZO, ALESSANDRO;CAVALIERE, Filomena Monica;IACOBINI, Metello;QUINTI, Isabella
2016

Abstract

The study of the expression of CD16, CD11b and Siglec 9 receptors and the oxidative burst provides insights on polymorphonuclear leukocytes (PMN) functionality in common variable immunodeficiency (CVID) and on the possible effects of intravenous immunoglobulin (IVIg) infusion. We evaluated in vivo before and soon after IVIg administration the CD16, CD11b and Siglec 9 expression on unstimulated and Escherichia coli-stimulated PMN and the oxidative burst induced by Escherichia coli and PMA. The E. coli stimulation up-regulated CD16 and Siglec 9 expression and it induced a strong CD11b up-regulation at baseline and soon after IVIg. The oxidative burst overlapped that observed in healthy donors when induced by Escherichia coli while it increased when induced by PMA. Soon after IVIg infusion, the oxidative burst decreased only when induced by PMA. Our results showed that the IVIg infusion in vivo had a minimal effect on CVID's PMN
IVIG; Neutrophils; CVID
01 Pubblicazione su rivista::01a Articolo in rivista
Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency / Prezzo, Alessandro; Cavaliere, Filomena Monica; Bilotta, C; Iacobini, Metello; Quinti, Isabella. - In: CELLULAR IMMUNOLOGY. - ISSN 0008-8749. - ELETTRONICO. - 307:306(2016), pp. 25-34. [10.1016/j.cellimm.2016.05.006]
File allegati a questo prodotto
File Dimensione Formato  
Prezzo_Intravenous-immunoglobulin_2016.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.45 MB
Formato Adobe PDF
1.45 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/901692
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact