Objective: Resting state electroencephalographic (EEG) rhythms are abnormal in multiple sclerosis (MS) patients, but it is unclear if they can reflect different neurophysiologic abnormalities in MS sub-types (phenotypes) such as relapsing-remitting (RR) and secondary progressive (SP). Methods: We tested whether cortical sources of resting state EEG rhythms are abnormal in MS patients and differ between MS phenotypes. Resting state eyes-closed EEG activity was recorded in 36 RR, 23 SP, and 41 matched healthy subjects. EEG bands of interest were individually identified based on Transition frequency (TF), Individual alpha frequency (IAF), and Individual beta frequency (IBF). LORETA freeware estimated cortical EEG sources. Results: Widespread TF -4 Hz (delta) and IAF (alpha) cortical sources were abnormal in the MS sub-groups compared to the control group. Furthermore, TF -4 Hz sources in central, parietal, and limbic regions were higher in amplitude in the SP compared to the RR sub-group. Conclusion: Cortical sources of resting state EEG rhythms are abnormal in MS patients at group level and differ between RR and SP sub-groups.

Cortical sources of resting state electroencephalographic rhythms differ in relapsing-remitting and secondary progressive multiple sclerosis / Babiloni, Claudio; Del Percio, Claudio; Capotosto, Paolo; Noce, Giuseppe; Infarinato, Francesco; Muratori, Chiara; Marcotulli, Christian; Bellagamba, Giovanni; Righi, Elena; Soricelli, Andrea; Onorati, Paolo; Lupattelli, Tommaso. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - ELETTRONICO. - 127:1(2016), pp. 581-590. [10.1016/j.clinph.2015.05.029]

Cortical sources of resting state electroencephalographic rhythms differ in relapsing-remitting and secondary progressive multiple sclerosis

BABILONI, CLAUDIO
;
Del Percio, Claudio;Noce, Giuseppe;MARCOTULLI, CHRISTIAN;ONORATI, Paolo;
2016

Abstract

Objective: Resting state electroencephalographic (EEG) rhythms are abnormal in multiple sclerosis (MS) patients, but it is unclear if they can reflect different neurophysiologic abnormalities in MS sub-types (phenotypes) such as relapsing-remitting (RR) and secondary progressive (SP). Methods: We tested whether cortical sources of resting state EEG rhythms are abnormal in MS patients and differ between MS phenotypes. Resting state eyes-closed EEG activity was recorded in 36 RR, 23 SP, and 41 matched healthy subjects. EEG bands of interest were individually identified based on Transition frequency (TF), Individual alpha frequency (IAF), and Individual beta frequency (IBF). LORETA freeware estimated cortical EEG sources. Results: Widespread TF -4 Hz (delta) and IAF (alpha) cortical sources were abnormal in the MS sub-groups compared to the control group. Furthermore, TF -4 Hz sources in central, parietal, and limbic regions were higher in amplitude in the SP compared to the RR sub-group. Conclusion: Cortical sources of resting state EEG rhythms are abnormal in MS patients at group level and differ between RR and SP sub-groups.
2016
electroencephalography (EEG); low-resolution brain electromagnetic tomography (LORETA); multiple sclerosis (MS); relapsing-remitting (RR); secondary progressive (SP); adult; apha rhythm; beta rhythm; brain waves; cerebral cortex; electroencephalography; female; humans; male; middle aged; multiple sclerosis, chronic progressive; multiple sclerosis, relapsing-remitting; rest; sensory systems; neurology; neurology (clinical); physiology (medical)
01 Pubblicazione su rivista::01a Articolo in rivista
Cortical sources of resting state electroencephalographic rhythms differ in relapsing-remitting and secondary progressive multiple sclerosis / Babiloni, Claudio; Del Percio, Claudio; Capotosto, Paolo; Noce, Giuseppe; Infarinato, Francesco; Muratori, Chiara; Marcotulli, Christian; Bellagamba, Giovanni; Righi, Elena; Soricelli, Andrea; Onorati, Paolo; Lupattelli, Tommaso. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - ELETTRONICO. - 127:1(2016), pp. 581-590. [10.1016/j.clinph.2015.05.029]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/900768
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