Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein ?3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.

Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine / Gentile, Giovanna; Borro, Marina; Lala, Noemi; Missori, Serena; Simmaco, Maurizio; Martelletti, Paolo. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - 11:5(2010), pp. 431-435. [10.1007/s10194-010-0241-0]

Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine

GENTILE, Giovanna;BORRO, Marina;LALA, NOEMI;MISSORI, Serena;SIMMACO, Maurizio;MARTELLETTI, Paolo
2010

Abstract

Migraine is a common type of headache and its most severe attacks are usually treated with triptans, the efficacy of which is extremely variable. Several SNPs in genes involved in metabolism and target mechanisms of triptans have been described. To define an association between genetic profile and triptan response, we classified a migrainous population on the basis of triptan response and characterized it for polymorphisms in the genes coding for monoamine oxidase A, G protein ?3 and the cytochrome CYP1A2. Analysis of the association between genotypic and allelic frequencies of the analyzed SNPs and the grade of response to triptan administration showed a significant correlation for MAOA uVNTR polymorphism. Further stratification of patients in abuser and non-abuser groups revealed a significant association with triptan overuse and, within the abusers, with drug response to the CYP1A2*1F variant.
2010
Chronic migraine; Polymorphisms; SNPs; Triptan efficacy; Triptan overuse; Adult; Aged; Aged, 80 and over; Chronic Disease; Cytochrome P-450 CYP1A2; Female; Gene Frequency; Genotype; Heterotrimeric GTP-Binding Proteins; Humans; Male; Middle Aged; Migraine Disorders; Minisatellite Repeats; Monoamine Oxidase; Pharmacogenetics; Polymorphism, Single Nucleotide; Substance-Related Disorders; Tryptamines; Anesthesiology and Pain Medicine; Neurology (clinical)
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Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine / Gentile, Giovanna; Borro, Marina; Lala, Noemi; Missori, Serena; Simmaco, Maurizio; Martelletti, Paolo. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - 11:5(2010), pp. 431-435. [10.1007/s10194-010-0241-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/900444
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