Background: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction. The aims of this study were to evaluate the correlation between serum UA and intrarenal arterial stiffness evaluated by Doppler ultrasound in SSc patients with normal renal function. We also evaluated the correlation between serum UA and other clinical variables of the disease. Methods: Forty-five SSc patients underwent clinical assessment, Doppler ultrasound of intrarenal arteries with evaluation of resistive index (RI), pulsatile index (PI), and systolic/diastolic ratio (S/D), echocardiography with systolic pulmonary artery pressure (PAPs), baseline pulmonary function tests, and nailfold videocapillaroscopy (NVC). In all patients serum UA was measured. Results: The serum UA showed a significant positive correlation with sCr (r = 0.33, p < 0.0001) and PAPs (r = 0.38, p < 0.01) > and negative correlation with CKD-EPI (r = -0.35, p < 0.01). The mean value of serum UA increased with severity of NVC damage. Using this cut-off value of 4.7 mg/dl, the mean value of Doppler indices of intrarenal stiffness is significantly different (p < 0.05) in SSc patients with low normal or high normal serum UA. Conclusions: Serum UA concentration is higher in patients with high microvascular damage than in patients with low microvascular damage. These preliminary data must be confirmed in large prospective studies.

Serum uric acid as a marker of microvascular damage in systemic sclerosis patients / Gigante, Antonietta; Barbano, Biagio; Barilaro, Giuseppe; Quarta, Silvia; Gasperini, Maria Ludovica; Di Mario, Francesca; Romaniello, Antonella; Amoroso, Antonio; Cianci, Rosario; Rosato, Edoardo. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - STAMPA. - 106:(2016), pp. 39-43. [10.1016/j.mvr.2016.03.007]

Serum uric acid as a marker of microvascular damage in systemic sclerosis patients

GIGANTE, ANTONIETTA;BARBANO, BIAGIO;Barilaro, Giuseppe;Gasperini, Maria Ludovica;AMOROSO, Antonio;CIANCI, ROSARIO;ROSATO, Edoardo
2016

Abstract

Background: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction. The aims of this study were to evaluate the correlation between serum UA and intrarenal arterial stiffness evaluated by Doppler ultrasound in SSc patients with normal renal function. We also evaluated the correlation between serum UA and other clinical variables of the disease. Methods: Forty-five SSc patients underwent clinical assessment, Doppler ultrasound of intrarenal arteries with evaluation of resistive index (RI), pulsatile index (PI), and systolic/diastolic ratio (S/D), echocardiography with systolic pulmonary artery pressure (PAPs), baseline pulmonary function tests, and nailfold videocapillaroscopy (NVC). In all patients serum UA was measured. Results: The serum UA showed a significant positive correlation with sCr (r = 0.33, p < 0.0001) and PAPs (r = 0.38, p < 0.01) > and negative correlation with CKD-EPI (r = -0.35, p < 0.01). The mean value of serum UA increased with severity of NVC damage. Using this cut-off value of 4.7 mg/dl, the mean value of Doppler indices of intrarenal stiffness is significantly different (p < 0.05) in SSc patients with low normal or high normal serum UA. Conclusions: Serum UA concentration is higher in patients with high microvascular damage than in patients with low microvascular damage. These preliminary data must be confirmed in large prospective studies.
2016
Endothelial dysfunction; Nailfold videocapillaroscopy; Renal Doppler ultrasound; Systemic sclerosis; Systolic pulmonary artery pressure microvascular damage; Uric acid; Biochemistry; Cardiology and Cardiovascular Medicine; Cell Biology
01 Pubblicazione su rivista::01a Articolo in rivista
Serum uric acid as a marker of microvascular damage in systemic sclerosis patients / Gigante, Antonietta; Barbano, Biagio; Barilaro, Giuseppe; Quarta, Silvia; Gasperini, Maria Ludovica; Di Mario, Francesca; Romaniello, Antonella; Amoroso, Antonio; Cianci, Rosario; Rosato, Edoardo. - In: MICROVASCULAR RESEARCH. - ISSN 0026-2862. - STAMPA. - 106:(2016), pp. 39-43. [10.1016/j.mvr.2016.03.007]
File allegati a questo prodotto
File Dimensione Formato  
Gigante_serum-uric-acid_2016.pdf

accesso aperto

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 362.14 kB
Formato Adobe PDF
362.14 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/899512
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 20
social impact