NTRODUCTION: This review will first discuss evidence of motor and sensory abnormalities as yielded by neurophysiological techniques in patients with PD. It will then go on to describe the effects of L-dopa replacement on motor and sensory abnormalities in PD as assessed by neurophysiological studies. AREAS COVERED: We analyzed papers in English using Pubmed with the following keywords: L-dopa, dopamine, bradykinesia, basal ganglia, kinematic analysis, TMS, motor cortex plasticity, motor cortex excitability, somatosensory discrimination threshold, pain Expert commentary: L-dopa improves the amplitude and speed of upper limb voluntary movements, but it does not restore abnormalities in the sequence effect or voluntary facial movements. L-dopa only partially normalizes changes in motor cortex excitability and plasticity and has also contrasting effects on the sensory system and on sensory-motor integration. The neurophysiological studies reviewed here show that PD is more than a hypo-dopaminergic disease, and non-dopaminergic mechanisms should also be considered.

The effect of L-dopa in Parkinson's disease as revealed by neurophysiological studies of motor and sensory functions / Suppa, Antonio; Bologna, Matteo; Conte, Antonella; Berardelli, Alfredo; Fabbrini, Giovanni. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - ELETTRONICO. - 12:(2016), pp. 1-12-12. [10.1080/14737175.2016.1219251]

The effect of L-dopa in Parkinson's disease as revealed by neurophysiological studies of motor and sensory functions

SUPPA, ANTONIO;BOLOGNA, Matteo;CONTE, ANTONELLA;BERARDELLI, Alfredo;FABBRINI, Giovanni
2016

Abstract

NTRODUCTION: This review will first discuss evidence of motor and sensory abnormalities as yielded by neurophysiological techniques in patients with PD. It will then go on to describe the effects of L-dopa replacement on motor and sensory abnormalities in PD as assessed by neurophysiological studies. AREAS COVERED: We analyzed papers in English using Pubmed with the following keywords: L-dopa, dopamine, bradykinesia, basal ganglia, kinematic analysis, TMS, motor cortex plasticity, motor cortex excitability, somatosensory discrimination threshold, pain Expert commentary: L-dopa improves the amplitude and speed of upper limb voluntary movements, but it does not restore abnormalities in the sequence effect or voluntary facial movements. L-dopa only partially normalizes changes in motor cortex excitability and plasticity and has also contrasting effects on the sensory system and on sensory-motor integration. The neurophysiological studies reviewed here show that PD is more than a hypo-dopaminergic disease, and non-dopaminergic mechanisms should also be considered.
2016
Levodopa; Parkinson disease; kinematic; motor cortex excitability; motor cortex plasticity; sequence effect; somatosensory temporal discrimination threshold
01 Pubblicazione su rivista::01a Articolo in rivista
The effect of L-dopa in Parkinson's disease as revealed by neurophysiological studies of motor and sensory functions / Suppa, Antonio; Bologna, Matteo; Conte, Antonella; Berardelli, Alfredo; Fabbrini, Giovanni. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - ELETTRONICO. - 12:(2016), pp. 1-12-12. [10.1080/14737175.2016.1219251]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/897760
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