BACKGROUND: Polyomaviruses (PyVs) are potential transforming viruses. Despite their involvement in human tumours still being debated, there is evidence to suggest a role for PyVs in bladder carcinoma (BC). Therefore, a possible association between PyVs and BC was investigated. MATERIALS AND METHODS: Urine, blood and fresh bladder tissue specimens were collected from 29 patients with BC. PyV prevalence, non-coding control region (NCCR) organization and genotypic analysis were assessed. RESULTS: Data showed a significant prevalence of John Cunningham (JC) PyV in BC tissues and in urine with respect to BKPyV, while simian virus 40 was not revealed. A BKPyV rearranged NCCR sequence was isolated, whereas a JCPyV archetypal structure was consistently retained. A prevalence of European genotypes was observed. CONCLUSION: Our data would suggest a JCPyV involvement in cancer progression and a BKPyV association with BC pathogenesis in immunocompetent patients. However, further work is necessary to better understand the exact role of PyVs in urothelial carcinogenesis.

Archetype and rearranged non-coding control regions (NCCR) in urothelial bladder carcinoma of immunocompetent individuals / Anzivino, Elena; Zingaropoli, Maria Antonella; Iannetta, Marco; Pietropaolo, Valeria Antonietta; Oliva, Alessandra; Iori, Francesco; Ciardi, Antonio; Rodio, Donatella Maria; Antonini, Francesca; Fedele, Cesare Giovanni; D'Abramo, Alessandra; Mastroianni, Cm; Vullo, Vincenzo; Ciardi, Maria Rosa. - In: CANCER GENOMICS & PROTEOMICS. - ISSN 1790-6245. - ELETTRONICO. - 13:6(2016), pp. 499-509. [10.21873/cgp.20013]

Archetype and rearranged non-coding control regions (NCCR) in urothelial bladder carcinoma of immunocompetent individuals

ANZIVINO, ELENA
Primo
;
ZINGAROPOLI, MARIA ANTONELLA
Secondo
;
IANNETTA, MARCO;PIETROPAOLO, Valeria Antonietta;OLIVA, ALESSANDRA;IORI, Francesco;CIARDI, Antonio;RODIO, DONATELLA MARIA;ANTONINI, FRANCESCA;D'ABRAMO, ALESSANDRA;Mastroianni, CM
Supervision
;
VULLO, Vincenzo
Penultimo
;
CIARDI, Maria Rosa
Ultimo
2016

Abstract

BACKGROUND: Polyomaviruses (PyVs) are potential transforming viruses. Despite their involvement in human tumours still being debated, there is evidence to suggest a role for PyVs in bladder carcinoma (BC). Therefore, a possible association between PyVs and BC was investigated. MATERIALS AND METHODS: Urine, blood and fresh bladder tissue specimens were collected from 29 patients with BC. PyV prevalence, non-coding control region (NCCR) organization and genotypic analysis were assessed. RESULTS: Data showed a significant prevalence of John Cunningham (JC) PyV in BC tissues and in urine with respect to BKPyV, while simian virus 40 was not revealed. A BKPyV rearranged NCCR sequence was isolated, whereas a JCPyV archetypal structure was consistently retained. A prevalence of European genotypes was observed. CONCLUSION: Our data would suggest a JCPyV involvement in cancer progression and a BKPyV association with BC pathogenesis in immunocompetent patients. However, further work is necessary to better understand the exact role of PyVs in urothelial carcinogenesis.
BKPyV; polyomaviruses; PyVs; urothelial bladder carcinoma
01 Pubblicazione su rivista::01a Articolo in rivista
Archetype and rearranged non-coding control regions (NCCR) in urothelial bladder carcinoma of immunocompetent individuals / Anzivino, Elena; Zingaropoli, Maria Antonella; Iannetta, Marco; Pietropaolo, Valeria Antonietta; Oliva, Alessandra; Iori, Francesco; Ciardi, Antonio; Rodio, Donatella Maria; Antonini, Francesca; Fedele, Cesare Giovanni; D'Abramo, Alessandra; Mastroianni, Cm; Vullo, Vincenzo; Ciardi, Maria Rosa. - In: CANCER GENOMICS & PROTEOMICS. - ISSN 1790-6245. - ELETTRONICO. - 13:6(2016), pp. 499-509. [10.21873/cgp.20013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/897367
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