In the bone marrow transplant setting, several authors hypothesized that severely overweight patients are at increased risk of transplant-related toxicity, but different definitions of obesity, different body weight groupings and heterogeneous samples of patients were analyzed. To overcome these limitations, we retrospectively considered a homogeneous group of 54 patients (median age 36.5 years), with a diagnosis of de novo acute myeloid leukemia (AML), autografted in first complete remission (CR) with the Bu-Cy2 conditioning regimen, dosed on actual body weight. Patients were classified into three groups (obese, non-obese, underweight) using body mass index (BMI = kg/m2); for each group we analyzed transplant-related toxicity and mortality, overall survival and disease-free survival (OS/DFS). In spite of the relatively small number of patients, in our results high BMI appears a predictive factor for an increase of treatment-related toxicity and mortality. Moreover, 30 (55%) patients are currently alive in continuous CR, and after a median follow-up of 76.5 months (range 14-137) statistically significant differences in OS and DFS were detected between obese and non-obese groups (P = 0.012 and 0.021, respectively). Our study suggests that obesity may represent an independent risk factor for autograft in AML and further investigations are warranted.

Obesity and autologous stem cell transplantation in acute myeloid leukemia / Meloni, Giovanna; A., Proia; S., Capria; A., Romano; G., Trap; S. M., Trisolini; Vignetti, Marco; Mandelli, Franco. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - STAMPA. - 28:4(2001), pp. 365-367. [10.1038/sj.bmt.1703145]

Obesity and autologous stem cell transplantation in acute myeloid leukemia

MELONI, Giovanna;VIGNETTI, Marco;MANDELLI, Franco
2001

Abstract

In the bone marrow transplant setting, several authors hypothesized that severely overweight patients are at increased risk of transplant-related toxicity, but different definitions of obesity, different body weight groupings and heterogeneous samples of patients were analyzed. To overcome these limitations, we retrospectively considered a homogeneous group of 54 patients (median age 36.5 years), with a diagnosis of de novo acute myeloid leukemia (AML), autografted in first complete remission (CR) with the Bu-Cy2 conditioning regimen, dosed on actual body weight. Patients were classified into three groups (obese, non-obese, underweight) using body mass index (BMI = kg/m2); for each group we analyzed transplant-related toxicity and mortality, overall survival and disease-free survival (OS/DFS). In spite of the relatively small number of patients, in our results high BMI appears a predictive factor for an increase of treatment-related toxicity and mortality. Moreover, 30 (55%) patients are currently alive in continuous CR, and after a median follow-up of 76.5 months (range 14-137) statistically significant differences in OS and DFS were detected between obese and non-obese groups (P = 0.012 and 0.021, respectively). Our study suggests that obesity may represent an independent risk factor for autograft in AML and further investigations are warranted.
2001
aml; autograft; obesity
01 Pubblicazione su rivista::01a Articolo in rivista
Obesity and autologous stem cell transplantation in acute myeloid leukemia / Meloni, Giovanna; A., Proia; S., Capria; A., Romano; G., Trap; S. M., Trisolini; Vignetti, Marco; Mandelli, Franco. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - STAMPA. - 28:4(2001), pp. 365-367. [10.1038/sj.bmt.1703145]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/89459
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