AIMS:HIV and highly active antiretroviral therapy (HAART) may affect cardiac conduction, and a higher incidence of sudden death has been recognized in HIV-positive patients. Nevertheless, predictors of prolonged corrected QT interval (cQT) have been poorly described. The aim of the study was to investigate the prevalence and predictors of long cQT in a cohort of HIV-positive patients. METHODS:Consecutive HIV-positive patients followed in a primary prevention clinic at two Italian institutions were retrospectively enrolled. A 12-lead ECG was recorded in all patients; main clinical features were collected. Prevalence of long cQT (defined as cQT >470 ms in women and >450 ms in men) was the primary end-point. Secondary end-points were the identification of predictors of cQT prolongation, and the association between HAART and HIV-related features with long cQT. RESULTS:Three hundred and fifty-one HIV-positive patients were included, 26 (7.4%) with long cQT. Mean age was higher among those with long cQT (51.6 vs. 57.6 years; P = 0.007). A higher prevalence of long cQT was reported for patients with a CD4+ cell count below 200 cells/μl at the moment of ECG (60 vs. 24.2%; P = 0.002) and with a nadir of CD4+ cell count below 200 cells/μl (91.3 vs. 58.6%; P = 0.001). At multivariate analysis, only the nadir of CD4+ cell count below 200 cells/μl consistently related to the presence of long cQT (odds ratio 5.8, 95% confidence interval 1.3-26.4). CONCLUSION: A low CD4+ cell count is associated with long cQT independently from HAART in HIV-positive patients and may be useful to correctly stratify arrhythmic risk in these patients.

Prevalence and predictors of long corrected QT interval in HIV-positive patients. a multicenter study / Gili, Sebastiano; Mancone, Massimo; Ballocca, Flavia; Grosso Marra, Walter; Calcagno, Andrea; D’Ettorre, Gabriella; Cannillo, Margherita; D’Ascenzo, Fabrizio; Orofino, Giancarlo; Marruncheddu, Laura; Lonni, Enrica; Cinque, Alessandra; Vullo, Francesco; Ceccarelli, Giancarlo; Vilardi, Ilaria; Sardella, Gennaro; Vullo, Vincenzo; Moretti, Claudio; Fedele, Francesco; Bonora, Stefano; Gaita, Fiorenzo. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2027. - ELETTRONICO. - 18:7(2017), pp. 539-544. [10.2459/JCM.0000000000000436]

Prevalence and predictors of long corrected QT interval in HIV-positive patients. a multicenter study

MANCONE, Massimo;D’Ettorre, Gabriella;MARRUNCHEDDU, LAURA;CINQUE, ALESSANDRA;VULLO, FRANCESCO;Ceccarelli, Giancarlo;SARDELLA, Gennaro;VULLO, Vincenzo;FEDELE, Francesco;
2017

Abstract

AIMS:HIV and highly active antiretroviral therapy (HAART) may affect cardiac conduction, and a higher incidence of sudden death has been recognized in HIV-positive patients. Nevertheless, predictors of prolonged corrected QT interval (cQT) have been poorly described. The aim of the study was to investigate the prevalence and predictors of long cQT in a cohort of HIV-positive patients. METHODS:Consecutive HIV-positive patients followed in a primary prevention clinic at two Italian institutions were retrospectively enrolled. A 12-lead ECG was recorded in all patients; main clinical features were collected. Prevalence of long cQT (defined as cQT >470 ms in women and >450 ms in men) was the primary end-point. Secondary end-points were the identification of predictors of cQT prolongation, and the association between HAART and HIV-related features with long cQT. RESULTS:Three hundred and fifty-one HIV-positive patients were included, 26 (7.4%) with long cQT. Mean age was higher among those with long cQT (51.6 vs. 57.6 years; P = 0.007). A higher prevalence of long cQT was reported for patients with a CD4+ cell count below 200 cells/μl at the moment of ECG (60 vs. 24.2%; P = 0.002) and with a nadir of CD4+ cell count below 200 cells/μl (91.3 vs. 58.6%; P = 0.001). At multivariate analysis, only the nadir of CD4+ cell count below 200 cells/μl consistently related to the presence of long cQT (odds ratio 5.8, 95% confidence interval 1.3-26.4). CONCLUSION: A low CD4+ cell count is associated with long cQT independently from HAART in HIV-positive patients and may be useful to correctly stratify arrhythmic risk in these patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/891667
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