Blood coagulation abnormalities induced by administration of E. coli L-asparaginase were investigated in 25 patients with acute lymphoblastic leukemia treated according to the GIMEMA ALL 0288 trial. Dosage of L-asparaginase was relatively low (6,000 U/m2/day for 7 days total dose 42,000 U/m2) as compared to the conventional dosages (120,000-140,000 U/m2 over 10-14 days). A significant decrease in fibronogen, plasminogen, alpha2-antiplasmin and antithrombin III was observed from day IV of L-asparaginase and it was maximum on day VIII, with return to the baseline levels on day XV. Protein C levels had only a borderline reduction, while no modification of protein S or factor VII was observed. Two of the patients investigated developed thrombosis. The presence of a prothrombotic state induced even by this low dosage of E. coli L-asparaginase was suggested by a significant increase of sensitive markers of hypercoagulability such as fibrinopeptide A, thrombin-antithrombin complexes, and prothrombin fragment F1 + 2.
EVIDENCE OF A HYPERCOAGULABLE STATE IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA TREATED WITH LOW-DOSE E. COLI L-ASPARAGINASE: A GIMEMA STUDY / Leone, L; Gugliotta, L; Mazzucconi, Maria Gabriella; DE STEFANO, V; MATTIOLI BELMONTE, M; Dragoni, F; Specchia, G; Centra, A; Gamba, G; Camera, A; Mandelli, F.. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - 69:(1993), pp. 12-15.
EVIDENCE OF A HYPERCOAGULABLE STATE IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA TREATED WITH LOW-DOSE E. COLI L-ASPARAGINASE: A GIMEMA STUDY
MAZZUCCONI, Maria Gabriella;
1993
Abstract
Blood coagulation abnormalities induced by administration of E. coli L-asparaginase were investigated in 25 patients with acute lymphoblastic leukemia treated according to the GIMEMA ALL 0288 trial. Dosage of L-asparaginase was relatively low (6,000 U/m2/day for 7 days total dose 42,000 U/m2) as compared to the conventional dosages (120,000-140,000 U/m2 over 10-14 days). A significant decrease in fibronogen, plasminogen, alpha2-antiplasmin and antithrombin III was observed from day IV of L-asparaginase and it was maximum on day VIII, with return to the baseline levels on day XV. Protein C levels had only a borderline reduction, while no modification of protein S or factor VII was observed. Two of the patients investigated developed thrombosis. The presence of a prothrombotic state induced even by this low dosage of E. coli L-asparaginase was suggested by a significant increase of sensitive markers of hypercoagulability such as fibrinopeptide A, thrombin-antithrombin complexes, and prothrombin fragment F1 + 2.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.