SULLA NATURA DELLA MIOSI E DELL'IPEREMIA CONGIUTIVALE DA SOMMINISTRAZIONE LOCALE DI FARMACI CON PROPRIETA BETA-SIMPATICOMIMETICHE (On the nature of the miosis and of the conjunctival hyperemia after topical administration of beta-sympathomimetic drugs)

Normal and glaucomatous patients have been examined. The Authors conclude as follows: l) Miosis and conjunctival hyperaemia after topical Buphenin (beta-agonist) and Oxprenolol (beta antagonist) resulted to be Atropine-resistent phenomenons. Parasimpathicomimetic system seems not to be involved. 2) The pretreatment with Indomethacin, to inhibit the synthesis of prostaglandins from their precursors, arachidonic acid, slightly reduced the intensity of such phenomenons. 3) By associating Pilocarpine to Oxprenolol an increase of the miosis but not of the hypotonizing effect was observed. The Authors think that in the action of such drugs, the « modulating » effect of the system AMPc + Prostaglandins is involved. To such a system, both the hypotonizing action and the miosis + conjunctival hyperaemia are to be referred.