Trifluoromethyl aldimines: an overview in the last ten years

The recent advances in the trifluoromethyl aldimine synthesis and reactivity were here reported. The relevance in the construction of various nitrogenated molecules enriched with a -CF3 substituent has prompted much research in this field, especially due to the increase of their use in the pharmaceutical field. Unlike their unfluorinated analogues, trifluoromethyl aldimines are good electrophiles owing to the electron-withdrawing effect of the -CF3 group and therefore have been largely studied in addition reactions, emerging as powerful building blocks to construct important molecules in many fields of application.