The spasmolytic activity of the essential oil from Hyssopus officinalis L. var. decumbens (HOD) and its major pure components, linalool, 1,8-cineole and limonene was studied on isolated guinea-pig ileum contracted by acetylcholine and BaCl2. HOD and linalool inhibited the acetylcholine- and BaCl2-induced contractions in a concentration-dependent manner (IC50 values: HOD, 37 mu g/mL and 60 mu g/mL; linalool 10 mu g/mL and 51 mu g/mL). The antagonism appeared non-competitive. In contrast, 1,8-cineole and limonene showed only a weak spasmogen action. (C) 1998 John Wiley & Sons, Ltd.
Spasmolytic action of the essential oil from Hyssopus officinalis L. var. decumbens and its major components / Mazzanti, Gabriela; M., Lu; G., Salvatore. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - STAMPA. - 12:1(1998), pp. S92-S94. (Intervento presentato al convegno 2nd International Symposium on Natural Drugs tenutosi a MELFI, ITALY nel SEP 28-OCT 01, 1997) [10.1002/(sici)1099-1573(1998)12:1+<s92::aid-ptr261>3.0.co;2-9].
Spasmolytic action of the essential oil from Hyssopus officinalis L. var. decumbens and its major components
MAZZANTI, Gabriela;
1998
Abstract
The spasmolytic activity of the essential oil from Hyssopus officinalis L. var. decumbens (HOD) and its major pure components, linalool, 1,8-cineole and limonene was studied on isolated guinea-pig ileum contracted by acetylcholine and BaCl2. HOD and linalool inhibited the acetylcholine- and BaCl2-induced contractions in a concentration-dependent manner (IC50 values: HOD, 37 mu g/mL and 60 mu g/mL; linalool 10 mu g/mL and 51 mu g/mL). The antagonism appeared non-competitive. In contrast, 1,8-cineole and limonene showed only a weak spasmogen action. (C) 1998 John Wiley & Sons, Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
