During long-term space missions, crew is subjected to potentially dangerous factors, among which cosmic radiations. Current technology is not able to totally protect astronauts from cosmic radiations. It is well known that, under these circumstances, the impairment in redox homeostasis induced by the over production of ROS can cause the onset of several diseases. In order to identify dietary supplements with particular high capability to overcome the oxidative impairment induced by cosmic/ionizing radiations, food supplement and pharmaceutical formulations containing plant bioactive molecules have been analyzed for their capability to counteract oxidative stress in in vitro and ex vivo experimental models. Particular attention has been given to green bioactive molecules obtained from food waste matrices. Food supplements/pharmaceutical formulations were analyzed and compared for their ROS-scavenging properties before and after the treatment with ionizing radiations (140 cSv, dose absorbed by astronauts after an hypothetical stay of three years in the space) as well as for their capability to protect red blood cell membranes from oxidative stress. Metabolomics characterization of the extracts, with particular attention to polyphenolic components, was also performed in order to identify the chemical profile alteration induced by ionizing radiations. The results obtained in this study showed that the analyzed extracts maintained their ROS scavenging capability after ionizing radiations exposure. These results could also have relavant positive effects in biomedicine: the intake of food supplements, or pharmaceutical formulations, rich in ROS-scavenging - bioactive molecules, could protect patients during radiotherapy or imaging and diagnostics analysis.
Plant Biology Europe EPSO-FESPB 2016 Praga / Pasqualetti, Valentina; Valletta, Alessio; Innocenti, Marzia; Mameli, Alessandra; Giuliani, Camilla; Angelis, Giulia De; Carnevale, Alessia; Mulinacci, Nadia; Pasqua, Gabriella; Gara, Laura De. - CD-ROM. - (2016). (Intervento presentato al convegno Plant Biology Europe EPSO-FESPB tenutosi a Praga).
Plant Biology Europe EPSO-FESPB 2016 Praga
VALLETTA, ALESSIO;PASQUA, Gabriella;
2016
Abstract
During long-term space missions, crew is subjected to potentially dangerous factors, among which cosmic radiations. Current technology is not able to totally protect astronauts from cosmic radiations. It is well known that, under these circumstances, the impairment in redox homeostasis induced by the over production of ROS can cause the onset of several diseases. In order to identify dietary supplements with particular high capability to overcome the oxidative impairment induced by cosmic/ionizing radiations, food supplement and pharmaceutical formulations containing plant bioactive molecules have been analyzed for their capability to counteract oxidative stress in in vitro and ex vivo experimental models. Particular attention has been given to green bioactive molecules obtained from food waste matrices. Food supplements/pharmaceutical formulations were analyzed and compared for their ROS-scavenging properties before and after the treatment with ionizing radiations (140 cSv, dose absorbed by astronauts after an hypothetical stay of three years in the space) as well as for their capability to protect red blood cell membranes from oxidative stress. Metabolomics characterization of the extracts, with particular attention to polyphenolic components, was also performed in order to identify the chemical profile alteration induced by ionizing radiations. The results obtained in this study showed that the analyzed extracts maintained their ROS scavenging capability after ionizing radiations exposure. These results could also have relavant positive effects in biomedicine: the intake of food supplements, or pharmaceutical formulations, rich in ROS-scavenging - bioactive molecules, could protect patients during radiotherapy or imaging and diagnostics analysis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.