The human teratocarcinoma derived growth factor 1 (TDGF1) gene maps on chromosome (Chr) 3p21.3. One pseudogene (TDGF3) maps on Chr Xq21-->q22. We now report the nucleotide sequence and chromosome location of three additional TDGF pseudogenes. The three new sequences (TDGF2, TDGF4 and TDGF5) are truncated at the 5' end and have accumulated several point mutations, deletions and insertions. TDGF2, TDGF4 and TDGF6 map on Chrs 2q37, 6p25 and 3q22, respectively. Finally, Southern blot analysis of DNA from normal individuals shows a highly variable restriction pattern of the TDGF sequences.

Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1 / Scognamiglio, B; Baldassarre, G; Cassano, C; Tucci, M; Montuori, N; Dono, R; Lembo, Giuseppe; Barra, A; Lago, C. T; Viglietto, G; Rocchi, M; Persico, M. G.. - In: CYTOGENETICS AND CELL GENETICS. - ISSN 0301-0171. - 84:3-4(1999), p. 220-4. [15263]

Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1

LEMBO, Giuseppe;
1999

Abstract

The human teratocarcinoma derived growth factor 1 (TDGF1) gene maps on chromosome (Chr) 3p21.3. One pseudogene (TDGF3) maps on Chr Xq21-->q22. We now report the nucleotide sequence and chromosome location of three additional TDGF pseudogenes. The three new sequences (TDGF2, TDGF4 and TDGF5) are truncated at the 5' end and have accumulated several point mutations, deletions and insertions. TDGF2, TDGF4 and TDGF6 map on Chrs 2q37, 6p25 and 3q22, respectively. Finally, Southern blot analysis of DNA from normal individuals shows a highly variable restriction pattern of the TDGF sequences.
1999
Alu Elements; Base Sequence; Blotting, Southern; Chromosomes, Artificial, Yeast; Chromosomes, Human; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 6; Cloning, Molecular; Exons; GPI-Linked Proteins; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Intercellular Signaling Peptides and Proteins; Introns; Mutation; Neoplasm Proteins; Pseudogenes; Templates, Genetic; Epidermal Growth Factor; Membrane Glycoproteins; Physical Chromosome Mapping
01 Pubblicazione su rivista::01a Articolo in rivista
Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1 / Scognamiglio, B; Baldassarre, G; Cassano, C; Tucci, M; Montuori, N; Dono, R; Lembo, Giuseppe; Barra, A; Lago, C. T; Viglietto, G; Rocchi, M; Persico, M. G.. - In: CYTOGENETICS AND CELL GENETICS. - ISSN 0301-0171. - 84:3-4(1999), p. 220-4. [15263]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/885550
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 11
social impact