The local anaesthetic activity of a number of compounds with different structures, contained in essential oils, was studied. Anaesthetic activity was evaluated in vivo in the rabbit conjunctival reflex test and in vitro in a rat phrenic nerve-hemidiaphragm technique. Among the substances tested terpineol and trans-anethole (10 -3-1μg/ml) were able to drastically reduce the electrically evoked contractions of rat phrenic nerve-hemidiaphragm in a concentration-dependent manner, but not eugenol, (-)- and (+)-citronellal, (-)- and (+)-carvone, trans cinnamaldehyde and α-terpinene. In the rabbit conjunctival reflex test, the treatment with a solution of terpineol and trans-anethole (10-100 μg/ml) effected a concentration-dependent increase in the number of stimuli required to evoke the reflex, thus confirming in vivo the local anaesthetic activity observed in vitro. Eugenol, (-)- and (+)-citronellal, trans-cinnamaldehyde, (-)- and (+)-carvone and α-terpinene were as ineffective in the in vivo test as they were in the in vitro results.
Local anaesthetic activity of monoterpenes and phenylpropanes of essential oils / Carla, Ghelardini; Nicoletta, Galeotti; Mazzanti, Gabriela. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 67:6(2001), pp. 564-566. [10.1055/s-2001-16475]
Local anaesthetic activity of monoterpenes and phenylpropanes of essential oils
MAZZANTI, Gabriela
2001
Abstract
The local anaesthetic activity of a number of compounds with different structures, contained in essential oils, was studied. Anaesthetic activity was evaluated in vivo in the rabbit conjunctival reflex test and in vitro in a rat phrenic nerve-hemidiaphragm technique. Among the substances tested terpineol and trans-anethole (10 -3-1μg/ml) were able to drastically reduce the electrically evoked contractions of rat phrenic nerve-hemidiaphragm in a concentration-dependent manner, but not eugenol, (-)- and (+)-citronellal, (-)- and (+)-carvone, trans cinnamaldehyde and α-terpinene. In the rabbit conjunctival reflex test, the treatment with a solution of terpineol and trans-anethole (10-100 μg/ml) effected a concentration-dependent increase in the number of stimuli required to evoke the reflex, thus confirming in vivo the local anaesthetic activity observed in vitro. Eugenol, (-)- and (+)-citronellal, trans-cinnamaldehyde, (-)- and (+)-carvone and α-terpinene were as ineffective in the in vivo test as they were in the in vitro results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.