Nucleic acid-binding core proteins (N.B.P.) coded by segments of the homologous gag gene of 18 retroviruses contain the motif CXXCXXXXHXXXXC. In the small N.B.P. (class A) the motif is single whereas in the larger N.B.P. (class B) it is repeated. It is suggested that these motifs form loops stabilized by the formation of a transition metal tetrahedral complex characterized by 3 cysteine residues and 1 histidine residue as ligands. Analogies with motifs present in transcription factors of eukaryotes suggest a regulatory role for the N.B.P. of retroviruses.
Structurally significant Motives in the primary Structure of RNA binding Proteins of Retroviruses including AIDS virus / LIQUORI A., M; Sadun, Claudia. - In: CHIMICA OGGI-CHEMISTRY TODAY. - ISSN 0392-839X. - STAMPA. - Apr:(1988), pp. 29-32.
Structurally significant Motives in the primary Structure of RNA binding Proteins of Retroviruses including AIDS virus
SADUN, Claudia
1988
Abstract
Nucleic acid-binding core proteins (N.B.P.) coded by segments of the homologous gag gene of 18 retroviruses contain the motif CXXCXXXXHXXXXC. In the small N.B.P. (class A) the motif is single whereas in the larger N.B.P. (class B) it is repeated. It is suggested that these motifs form loops stabilized by the formation of a transition metal tetrahedral complex characterized by 3 cysteine residues and 1 histidine residue as ligands. Analogies with motifs present in transcription factors of eukaryotes suggest a regulatory role for the N.B.P. of retroviruses.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
