Background: The role of a mixture of phlebotonics in the treatment of acute hemorrhoid crisis is investigated to test their efficacy. Methods: One hundred and thirty-four consecutive patients with an acute hemorrhoidal crisis recruited in five colorectal units entered the study. Sixty-six of them were randomized to receive a mixture of diosmin, troxerutin and hesperidin (group A), and 68 a placebo (group B). The main symptoms, the use of oral painkillers and the Bristol scale score were recorded at each scheduled visit and compared using both Student’s t test for independent samples and the ANOVA models for repeated measures. The presence of edema, prolapse and thrombosis were also recorded and compared using the Chi-square test. Furthermore, the trend of proportions during the time of the evaluations was assessed by the Chi-square test for linear trend. Results: Pain, bleeding and the proportion of patients who reported persistence of edema and thrombosis decreased significantly after 12 days of treatment in group A. After 6 days, the number of paracetamol tablets taken by patients in groupA was significantly lower than the amount of flavonoid mixture. Conclusions: The use of a mixture of diosmin, troxerutin and hesperidin is a safe and effective mean of managing symptoms of acute hemorrhoidal disease. Furthermore, in patients receiving treatment, there was faster control and lower persistence of edema and thrombosis.

Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease. A prospective, randomized, triple-blind, controlled trial / Giannini, I.; Amato, A.; Basso, Luigi; Tricomi, N.; Marranci, M.; Pecorella, G.; Tafuri, S.; Pennisi, D.; Altomare, D. F.. - In: TECHNIQUES IN COLOPROCTOLOGY. - ISSN 1123-6337. - STAMPA. - 19:6(2015), pp. 339-345. [DOI 10.1007/s10151-015-1302-9]

Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease. A prospective, randomized, triple-blind, controlled trial

BASSO, Luigi;
2015

Abstract

Background: The role of a mixture of phlebotonics in the treatment of acute hemorrhoid crisis is investigated to test their efficacy. Methods: One hundred and thirty-four consecutive patients with an acute hemorrhoidal crisis recruited in five colorectal units entered the study. Sixty-six of them were randomized to receive a mixture of diosmin, troxerutin and hesperidin (group A), and 68 a placebo (group B). The main symptoms, the use of oral painkillers and the Bristol scale score were recorded at each scheduled visit and compared using both Student’s t test for independent samples and the ANOVA models for repeated measures. The presence of edema, prolapse and thrombosis were also recorded and compared using the Chi-square test. Furthermore, the trend of proportions during the time of the evaluations was assessed by the Chi-square test for linear trend. Results: Pain, bleeding and the proportion of patients who reported persistence of edema and thrombosis decreased significantly after 12 days of treatment in group A. After 6 days, the number of paracetamol tablets taken by patients in groupA was significantly lower than the amount of flavonoid mixture. Conclusions: The use of a mixture of diosmin, troxerutin and hesperidin is a safe and effective mean of managing symptoms of acute hemorrhoidal disease. Furthermore, in patients receiving treatment, there was faster control and lower persistence of edema and thrombosis.
2015
Hemorrhoidal crisis; flavonoids; anal pain; anal bleeding; anal itching
01 Pubblicazione su rivista::01a Articolo in rivista
Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease. A prospective, randomized, triple-blind, controlled trial / Giannini, I.; Amato, A.; Basso, Luigi; Tricomi, N.; Marranci, M.; Pecorella, G.; Tafuri, S.; Pennisi, D.; Altomare, D. F.. - In: TECHNIQUES IN COLOPROCTOLOGY. - ISSN 1123-6337. - STAMPA. - 19:6(2015), pp. 339-345. [DOI 10.1007/s10151-015-1302-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/882201
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