Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

Hepatitis C virus relies on lipoproteins for its life cycle / Grassi, Germana; DI CAPRIO, Giorgia; Fimia, Gian Maria; Ippolito, Giuseppe; Tripodi, Marco; Alonzi, Tonino. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - ELETTRONICO. - 22:6(2016), pp. 1953-1965. [10.3748/wjg.v22.i6.1953]

Hepatitis C virus relies on lipoproteins for its life cycle

GRASSI, GERMANA;DI CAPRIO, GIORGIA;Fimia, Gian Maria;TRIPODI, Marco;ALONZI, TONINO
2016

Abstract

Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.
2016
Apolipoproteins; Hepatitis C virus; Lipid metabolism; Lipoproteins; Review; Gastroenterology
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatitis C virus relies on lipoproteins for its life cycle / Grassi, Germana; DI CAPRIO, Giorgia; Fimia, Gian Maria; Ippolito, Giuseppe; Tripodi, Marco; Alonzi, Tonino. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - ELETTRONICO. - 22:6(2016), pp. 1953-1965. [10.3748/wjg.v22.i6.1953]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/882106
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