Mesenchymal stromal cells (MSCs) have been largely investigated, in the past decade, as potential therapeutic strategies for various acute and chronic pathological conditions. MSCs isolated from different sources, such as bone marrow (BM), umbilical cord tissue (UCT) and adipose tissue (AT), share many biological features, although they may show some differences on cumulative yield, proliferative ability and differentiation potential. The standardization of MSCs growth and their functional amplification is a mandatory objective of cell therapies. The aim of this study was to evaluate the cumulative yield and the ex vivo amplification potential of MSCs obtained from various sources and different subjects, using defined culture conditions with a standardized platelet lysate (PL) as growth stimulus.

Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues / Fazzina, R; Iudicone, P; Fioravanti, D; Bonanno, G; Totta, P; Zizzari, I. G; Pierelli, Luca; Zizzari, ILARIA GRAZIA. - In: STEM CELL RESEARCH & THERAPY. - ISSN 1757-6512. - ELETTRONICO. - 7:1(2016). [10.1186/s13287-016-0383-3]

Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues

PIERELLI, LUCA;ZIZZARI, ILARIA GRAZIA
2016

Abstract

Mesenchymal stromal cells (MSCs) have been largely investigated, in the past decade, as potential therapeutic strategies for various acute and chronic pathological conditions. MSCs isolated from different sources, such as bone marrow (BM), umbilical cord tissue (UCT) and adipose tissue (AT), share many biological features, although they may show some differences on cumulative yield, proliferative ability and differentiation potential. The standardization of MSCs growth and their functional amplification is a mandatory objective of cell therapies. The aim of this study was to evaluate the cumulative yield and the ex vivo amplification potential of MSCs obtained from various sources and different subjects, using defined culture conditions with a standardized platelet lysate (PL) as growth stimulus.
2016
adipose tissue; bone marrow; culture standardization; mesenchymal stromal cells; platelet lysate; proliferative potential; umbilical cord tissue
01 Pubblicazione su rivista::01a Articolo in rivista
Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues / Fazzina, R; Iudicone, P; Fioravanti, D; Bonanno, G; Totta, P; Zizzari, I. G; Pierelli, Luca; Zizzari, ILARIA GRAZIA. - In: STEM CELL RESEARCH & THERAPY. - ISSN 1757-6512. - ELETTRONICO. - 7:1(2016). [10.1186/s13287-016-0383-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/881908
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