With the aim to obtain a scaffold with improved mechanical properties with respect to collagen for tendon augmentation and regeneration, a novel collagen-based material was prepared via heterogeneous phase derivatization of type I collagen sponges using polylactic acid. Compared to the untreated collagen, the functionalized sponge (Coll-PLA) was characterized by higher tensile properties and lower swelling capability; the degradation rate of Coll-PLA, in the presence of collagenase, was lower than that of the untreated collagen sponge. These results are related to an increased hydrophobic character of the collagen matrix due to the presence of PLA chains. In vitro tests, performed with human primary fibroblasts, showed that cell adhesion and proliferation rate on Coll-PLA were comparable to those obtained with the non-functionalized collagen. These findings suggest that the new biomaterial could be suitable as scaffold in tendon augmentation and regeneration. © 2016 Elsevier Ltd

PLA-grafting of collagen chains leading to a biomaterial with mechanical performances useful in tendon regeneration / Bellini, Davide; Cencetti, Claudia; Sacchetta, Anna Cristina; Battista, Angela Maria; Martinelli, Andrea; Mazzucco, Laura; SCOTTO D'ABUSCO, Anna; Matricardi, Pietro. - In: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. - ISSN 1751-6161. - STAMPA. - 64:(2016), pp. 151-160. [10.1016/j.jmbbm.2016.07.006]

PLA-grafting of collagen chains leading to a biomaterial with mechanical performances useful in tendon regeneration

CENCETTI, Claudia;MARTINELLI, Andrea;SCOTTO D'ABUSCO, ANNA;MATRICARDI, PIETRO
2016

Abstract

With the aim to obtain a scaffold with improved mechanical properties with respect to collagen for tendon augmentation and regeneration, a novel collagen-based material was prepared via heterogeneous phase derivatization of type I collagen sponges using polylactic acid. Compared to the untreated collagen, the functionalized sponge (Coll-PLA) was characterized by higher tensile properties and lower swelling capability; the degradation rate of Coll-PLA, in the presence of collagenase, was lower than that of the untreated collagen sponge. These results are related to an increased hydrophobic character of the collagen matrix due to the presence of PLA chains. In vitro tests, performed with human primary fibroblasts, showed that cell adhesion and proliferation rate on Coll-PLA were comparable to those obtained with the non-functionalized collagen. These findings suggest that the new biomaterial could be suitable as scaffold in tendon augmentation and regeneration. © 2016 Elsevier Ltd
2016
biomaterials; biomedical engineering; mechanics of materials
01 Pubblicazione su rivista::01a Articolo in rivista
PLA-grafting of collagen chains leading to a biomaterial with mechanical performances useful in tendon regeneration / Bellini, Davide; Cencetti, Claudia; Sacchetta, Anna Cristina; Battista, Angela Maria; Martinelli, Andrea; Mazzucco, Laura; SCOTTO D'ABUSCO, Anna; Matricardi, Pietro. - In: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS. - ISSN 1751-6161. - STAMPA. - 64:(2016), pp. 151-160. [10.1016/j.jmbbm.2016.07.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/881069
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