The aim of this study was the preparation of a very simple and, at the same time, innovative three-component in-situ gelling hydrogel, composed of hyaluronic acid, gellan gum and calcium chloride, for osteochondral defects reparation. The above mentioned biocompatible polymers were used in a smart combination for bone defects filling and capping, capable to form a very stable system that avoids the leakage of any material from it. The polymeric materials, obtained using various combinations of polymers/calcium ratios, were characterized in terms of rheological and dynamo-mechanical properties, degradation rate and adhesion to bone defects. In vitro biocompatibility tests, performed using human primary osteoblasts, showed that this novel system can be an ideal candidate for the regeneration of bone defects, potentially improving the surgery approach in this field

An in situ gelling system for bone regeneration of osteochondral defects / Davide, Bellini; Claudia, Cencetti; Joachim, Meraner; Stoppoloni, Daniela; SCOTTO D'ABUSCO, Anna; Matricardi, Pietro. - In: EUROPEAN POLYMER JOURNAL. - ISSN 0014-3057. - STAMPA. - 72:(2015), pp. 642-650. [10.1016/j.eurpolymj.2015.02.043]

An in situ gelling system for bone regeneration of osteochondral defects

STOPPOLONI, DANIELA;SCOTTO D'ABUSCO, ANNA;MATRICARDI, PIETRO
2015

Abstract

The aim of this study was the preparation of a very simple and, at the same time, innovative three-component in-situ gelling hydrogel, composed of hyaluronic acid, gellan gum and calcium chloride, for osteochondral defects reparation. The above mentioned biocompatible polymers were used in a smart combination for bone defects filling and capping, capable to form a very stable system that avoids the leakage of any material from it. The polymeric materials, obtained using various combinations of polymers/calcium ratios, were characterized in terms of rheological and dynamo-mechanical properties, degradation rate and adhesion to bone defects. In vitro biocompatibility tests, performed using human primary osteoblasts, showed that this novel system can be an ideal candidate for the regeneration of bone defects, potentially improving the surgery approach in this field
2015
bone defects; gellan gum; hyaluronic acid; in-situ hydrogel; rheology; tissue engineering; polymers and plastics; physics and astronomy (all); organic chemistry
01 Pubblicazione su rivista::01a Articolo in rivista
An in situ gelling system for bone regeneration of osteochondral defects / Davide, Bellini; Claudia, Cencetti; Joachim, Meraner; Stoppoloni, Daniela; SCOTTO D'ABUSCO, Anna; Matricardi, Pietro. - In: EUROPEAN POLYMER JOURNAL. - ISSN 0014-3057. - STAMPA. - 72:(2015), pp. 642-650. [10.1016/j.eurpolymj.2015.02.043]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/881024
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