Conventional theories and therapies for premature ejaculation (PE) are based on assumptions not always supported by evidence. This review of the current literature on the physiology of the ejaculatory control, pathogenesis of PE, and available therapies shows that PE is still far from being fully understood. However, several interesting hypotheses have been formulated, and solid, evidence-based clinical data are currently available for dapoxetine, the unique, first-line, officially approved pharmacotherapy for PE. Further growth in the field of PE will occur only when we shift from opinion-based classifications, definitions, and hypotheses to robust, noncontroversial data grounded on evidence.

Premature ejaculation: Old story, new insights / Jannini, Emmanuele A; Ciocca, Giacomo; Limoncin, Erika; Mollaioli, Daniele; DI SANTE, Stefania; Gianfrilli, Daniele; Lombardo, Francesco; Lenzi, Andrea. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - STAMPA. - 104:5(2015), pp. 1061-1073. [10.1016/j.fertnstert.2015.08.035]

Premature ejaculation: Old story, new insights

Ciocca, Giacomo;Limoncin, Erika;DI SANTE, STEFANIA;GIANFRILLI, DANIELE;LOMBARDO, Francesco;LENZI, Andrea
2015

Abstract

Conventional theories and therapies for premature ejaculation (PE) are based on assumptions not always supported by evidence. This review of the current literature on the physiology of the ejaculatory control, pathogenesis of PE, and available therapies shows that PE is still far from being fully understood. However, several interesting hypotheses have been formulated, and solid, evidence-based clinical data are currently available for dapoxetine, the unique, first-line, officially approved pharmacotherapy for PE. Further growth in the field of PE will occur only when we shift from opinion-based classifications, definitions, and hypotheses to robust, noncontroversial data grounded on evidence.
2015
Dapoxetine; premature ejaculation; serotonin; Obstetrics and Gynecology; Reproductive Medicine
01 Pubblicazione su rivista::01a Articolo in rivista
Premature ejaculation: Old story, new insights / Jannini, Emmanuele A; Ciocca, Giacomo; Limoncin, Erika; Mollaioli, Daniele; DI SANTE, Stefania; Gianfrilli, Daniele; Lombardo, Francesco; Lenzi, Andrea. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - STAMPA. - 104:5(2015), pp. 1061-1073. [10.1016/j.fertnstert.2015.08.035]
File allegati a questo prodotto
File Dimensione Formato  
Jannini_premature_2015.pdf

solo utenti autorizzati

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.04 MB
Formato Adobe PDF
1.04 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/880045
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 51
social impact