In man, cholesterol esterification is controlled by lecithin:cholesterol-acyl-transferase (LCAT), which is a key-role enzyme of lipid metabolism. Though LCAT is synthesized by the hepatocytes, its activity seems to be linked to the kidney: in fact, LCAT activity is lowered in uremic and anephric subjects, and probably also in long-term haemodialysis patients. On the contrary, in successfull renal allografts we found fully restored LCAT activity. But physiopathological mechanisms underlying relationships between LCAT and kidney are still unclarified.

[Esterification of cholesterol in patients with renal transplants. Determination of lecithin:cholesterol-acyl-transferase (LCAT) activity] / Ceccanti, Mauro; A., Berbellini; Nardi, EMANUELE ANTONINO; Palestini, Massimo; Romeo, Marina; Sasso, Guido; Tersigni, Roberto. - In: MINERVA CHIRURGICA. - ISSN 0026-4733. - STAMPA. - 35:10(1980), pp. 723-726.

[Esterification of cholesterol in patients with renal transplants. Determination of lecithin:cholesterol-acyl-transferase (LCAT) activity].

CECCANTI, Mauro;NARDI, EMANUELE ANTONINO;PALESTINI, Massimo;ROMEO, Marina;SASSO, Guido;TERSIGNI, Roberto
1980

Abstract

In man, cholesterol esterification is controlled by lecithin:cholesterol-acyl-transferase (LCAT), which is a key-role enzyme of lipid metabolism. Though LCAT is synthesized by the hepatocytes, its activity seems to be linked to the kidney: in fact, LCAT activity is lowered in uremic and anephric subjects, and probably also in long-term haemodialysis patients. On the contrary, in successfull renal allografts we found fully restored LCAT activity. But physiopathological mechanisms underlying relationships between LCAT and kidney are still unclarified.
esterification; kidney transplantation; cholesterol; phosphatidylcholine-sterol o-acyltransferase
01 Pubblicazione su rivista::01a Articolo in rivista
[Esterification of cholesterol in patients with renal transplants. Determination of lecithin:cholesterol-acyl-transferase (LCAT) activity] / Ceccanti, Mauro; A., Berbellini; Nardi, EMANUELE ANTONINO; Palestini, Massimo; Romeo, Marina; Sasso, Guido; Tersigni, Roberto. - In: MINERVA CHIRURGICA. - ISSN 0026-4733. - STAMPA. - 35:10(1980), pp. 723-726.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/87930
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