Introduction. Alcoholic hepatitis (AH) is an acute-on-chronic inflammatory response affecting the liver. It has been recognized that white blood cells (WBCs) are involved in the pathogenesis and in the prognosis of AH. The aim of study was to use Adacolumn, which can selectively adsorb myeloid linage leucocytes (granulocytes and monocytes/ macrophages) from the blood in the column and improve the clinical status of patients Conclusions. The Adacolumn apheresis was safe and was able to determine an improvement of clinical status of patients with reduction of inflammatory markers. More patients are needed to validate these results.
Alcoholic hepatitis (AH) is an acute-on-chronic inflammatory response affecting the liver. It has been recognized that white blood cells (WBCs) are involved in the pathogenesis and in the prognosis of AH. The aim of study was to use Adacolumn, which can selectively adsorb myeloid linage leucocytes (granulocytes and monocytes/macrophages) from the blood in the column and improve the clinical status of patients.
Adacolumn granulocyte-apheresis for alcoholic hepatitis. Preliminary study / Morabito, VINCENZO EMILIANO; Novelli, Simone; Poli, Luca; Ferretti, G; Ruberto, F; Pugliese, Francesco; Pretagostini, Renzo; Berloco, P. B; Rossi, Massimo. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - STAMPA. - 48:2(2016), pp. 352-358. [10.1016/j.transproceed.2015.12.055]
Adacolumn granulocyte-apheresis for alcoholic hepatitis. Preliminary study
MORABITO, VINCENZO EMILIANO;NOVELLI, SIMONE;POLI, Luca;PUGLIESE, Francesco;PRETAGOSTINI, Renzo;ROSSI, MASSIMO
2016
Abstract
Introduction. Alcoholic hepatitis (AH) is an acute-on-chronic inflammatory response affecting the liver. It has been recognized that white blood cells (WBCs) are involved in the pathogenesis and in the prognosis of AH. The aim of study was to use Adacolumn, which can selectively adsorb myeloid linage leucocytes (granulocytes and monocytes/ macrophages) from the blood in the column and improve the clinical status of patients Conclusions. The Adacolumn apheresis was safe and was able to determine an improvement of clinical status of patients with reduction of inflammatory markers. More patients are needed to validate these results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
